Non-steroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors (coxibs) enjoy widespread use in clinical practice, leading to a remarkable frequency of unwanted renal side effects. In most cases, NSAID-induced acute renal failure or acute kidney injury is hemodynamically mediated. Clinical syndromes associated with NSAID use include acute renal failure, acute interstitial nephritis, worsening of chronic kidney disease (CKD), salt and water retention and hypertension. Careful monitoring of renal function is advisable in patients at increased risk such as elderly individuals with compromised cardiac reserve, and diabetics.
BennettW.M., HenrichW.L., StoffJ.S.The renal effects of nonsteroidal anti-inflammatory drugs: summary and recommendations. Am J Kidney Dis1996; 28(Suppl 1): S56–62.
3.
KleinknechtD., LandaisP., GoldfarbB.Analgesic and non-steroidal anti-inflammatory drug-associated acute renal failure: a prospective collaborative study. Clin Nephrol1986; 25: 275–81.
4.
HuertaC., CastellsagueJ., Varas-LorenzoC., Garcia RodriguezL.A.Nonsteroidal anti-inflammatory drugs and risk of ARF in the general population. Am J Kidney Dis2005; 45: 531–9.
5.
PernegerT.V., WheltonP.K., KlagM.J.Risk of kidney failure associated with the use of acetaminophen, aspirin, and nonsteroidal antiinflammatory drugs. N Engl J Med1994; 331: 1675–9.
6.
GambaroG., PerazellaM.A.Adverse renal effects of anti-inflammatory agents: evaluation of selective and nonselective cyclooxygenase inhibitors. J Intern Med2003; 253: 643–52.
7.
GarellaS., MatareseR.A.Renal effects of prostaglandins and clinical adverse effects of nonsteroidal anti-inflammatory agents. Medicine (Baltimore)1984; 63: 165–81.
8.
SchneiderV., LevesqueL.E., ZhangB.Association of selective and conventional nonsteroidal antiinflammatory drugs with acute renal failure: A population-based, nested case-control analysis. Am J Epidemiol2006; 164: 881–9.
9.
DzauV.J.Vascular and renal prostaglandins as counter-regulatory systems in heart failure. Eur Heart J1988; 9(Suppl H): 15–9.
10.
AudolyL.P., RoccaB., FabreJ.E.Cardiovascular responses to the isoprostanes iPF(2alpha)-III and iPE-III are mediated via the thromboxane A receptor in vivo. Circulation2000; 101: 2833–40.
11.
GoochK., CulletonB.F., MannsB.J.NSAID use and pro-gression of chronic kidney disease. Am J Med2007; 120: 280.e1–7.
12.
HickeyE.J., RajeR.R., ReidV.E.Diclofenac induced in vivo nephrotoxicity may involve oxidative stress-mediated massive genomic DNA fragmentation and apoptotic cell death. Free Radic Biol Med2001; 31: 139–52.
13.
MolitorisB.A., SuttonT.A.Endothelial injury and dysfunction: role in the extension phase of acute renal failure. Kidney Int2004; 66: 496–9.
YinC., KnudsonC.M., KorsmeyerS.J., Van DykeT.Bax sup-presses tumorigenesis and stimulates apoptosis in vivo. Nature1997; 385: 637–40.
16.
KandasamyK., SrinivasulaS.M., AlnemriE.S.Involvement of proapoptotic molecules Bax and Bak in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced mitochondrial disruption and apoptosis: differential regulation of cytochrome c and Smac/DIABLO release. Cancer Res63: 1712–1721, 2003
17.
BrezinJ.H., KatzS.M., SchwartzA.B., ChinitzJ.L.Reversible renal failure and nephrotic syndrome associated with nonsteroidal anti-inflammatory drugs. N Engl J Med1979; 301: 1271–3.
18.
SinghalP.C., FaulknerM., VenkatesanJ., MolhoL.Hypersensitivity angiitis associated with naproxen. Ann Allergy 63; 1989: 107–9.
19.
BreyerM.D., HaoC., QiZ.Cyclooxygenase-2 selective inhibitors and the kidney. Curr Opin Crit Care2001; 7: 393–400.
20.
HarrisR.C.JrCyclooxygenase-2 inhibition and renal physiology. Am J Cardiol2002; 89: 10D–7.
21.
FrishmanW.H.Effects of nonsteroidal anti-inflammatory drug therapy on blood pressure and peripheral edema. Am J Cardiol2002; 89: 18D–25.
22.
FindlingJ.W., BeckstromD., RawsthorneL.Indomethacin-induced hyperkalemia in three patients with gouty arthritis. JAMA1980; 244: 1127–8.
