Pyrrolidine dithiocarbamate (PDTC) can be an oral chelator with pKa= 3.300±0.002. It behaves as a bidentate ligand at serum pH. The effect of pH on Ni2+-Tf indicated that the maximum adsorption was at pH=7.4. The effective Ni-PDTC binding constant was determined (logk=11.1±0.1) for the 1:2 Ni(PDTC)2 complex using UV-vis spectra. The isosbestic point at 298 indicated that the complexation reaction was done directly (without side reaction). Removal of Ni from transferrin (Tf) was investigated by reverse titration of PDTC at 25°C and pH=7.4 using UV-vis spectra. PDTC is able to remove 25% of Ni from human serum transferrin.
CigadaA., RondelliG., VicentiniB., BrunellaF., DallaspeziaG.Corrosion behavior of high nitrogen stainless steels for biomedical applications. In: KovacsP.B., IstephanousN.S., eds. Compatibility of biomedical implants.Pennington, New Jersey: The Electrochemical Society, Inc.; 1994. p 185–95.
2.
HildebrandH.F., VeronC., MartinP.Nickel, chromium, cobalt dental alloys and allergic reactions: An overview. Biomaterials1989; 10: 545–8.
3.
WilliamsD.F.Encyclopedia of medical and dental materials.Oxford: Pergamon Press; 1990.
4.
MullerW.J., MaessenFJMJ, DavidsonC.L.Determination of the corrosion rates of six dental NiCrMo alloys in an artificial saliva by chemical analysis of the medium using ICP-AES. Dent Mater1990; 6: 63–8.
5.
PereiraM.C., PereiraM.L., SousaJ.P.Evaluation of nickel toxicity on liver, spleen, and kidney of mice after administration of high-dose metal ion. J Biomed Mater Res1998; 40: 40–7.
6.
CooganT.P., LattaD.M., SnowE.T., CostaM.Toxicity and carcinogenicity of nickel compounds. CRC Crit Rev Toxicol1989; 19: 341–84.
7.
SundermanF.W., DonnellyA.J.Studies of nickel carcinogenesis metastasizing pulmonary tumors in rats induced by the inhalation of nickel carbonyl. Am J Pathol1965; 46: 1027–41.
8.
ChasteenN.D.Transferrin: A perspective. Adv Inorg Biochem1983; 5: 201–33.
9.
HarrisD.C., AisenP.Physical biochemistry of the transferrins. In: LochrT.M., ed. Iron carriers and iron proteins.New York: VCH Publishers; 1989. p 239–352.
10.
SarraR., GarrattR., GorinskyB., JhotiH., LindleyP.High resolution X-ray studies on rabbit serum transferring-preliminary structure-analysis of the N-terminal half-molecule at 2.3-a resolution. Acta Crystallogr1990; 46: 763–71.
PerezG., PregiN., VittoriD., Di RisioC., GarbossaG., NesseA.Aluminum exposure affects transferrin-dependent and - independent iron uptake by K562 cells. Biochim Biophys Acta2005; 1745: 124–30.
13.
SmithT.A.D., Human serum transferrin cobalt complex: Stability and cellular uptake of cobalt. Bioorg Med Chem2005; 13: 4576–9.
14.
HarrisW.R.Estimation of the ferrous-transferrin binding constants based on thermodynamic studies of nickel(II)-transferrin. J Inorg Biochem1986; 27: 41–52.
15.
IsekiA., KambeF., OkumuraK., HayakawaT., SeoH.Regulation of thyroid follicular cell function by intracellular redox-active copper. Endocrinology2000; 141: 4373–82.
16.
ToppingR.J., JonesM.M.Optimal dithiocarbamate structure for immunomodulator action. Med Hypotheses1988; 27: 55–7.
17.
ThornG.D., LudwigR.A.The dithiocarbamates and related compounds.Amsterdam: Elsevier Publishing Company; 1962.
18.
LangJ-M, TrepoC., KirstetterM., HerviouL., RetornazG., RenouxG., MussetM., TourainemJ-L, ChoutetP., FalkenrodA., LiverozetJ-M, TouraineF., CarauxJ.Randomised, double-blind, placebo-controlled trial of ditiocarb sodium “Imuthiol” in human immunodeficiency virus infection. Lancet1988; 2: 702–6.
19.
SundermanF.W.Studies of nickel carcinogenesis metastasizing pulmonary tumors in rats induced by the inhalation of nickel carbonyl. J New Drugs1964; 4: 154–61.
20.
HarrisW.R., SheldonJ.Equilibrium constants for the binding of aluminum to human serum transferring. Inorg Chem1990; 29: 119–24.
21.
VosburghW.C., CooperG.R.Complex ions. I. The identification of complex Ions in solution by spectrophotometric measurements. J Am Chem Soc1941; 63: 437–42.
22.
FatemiS.J., KadirF.H.A., MooreG.R.Aluminium transport in blood serum. Binding of aluminium by human transferrin in the presence of human albumin and citrate. Biochem J1990; 280: 527–32.
