Foscarnet is an antiviral agent widely used in the treatment of cytomegalovirus (CMV) infection. We describe a cardiac transplant patient, who while being maintained with hemodialysis because of tobramycin-induced acute renal failure, was given Foscarnet for disseminated CMV infection. Using dialysate-side clearance methodology, we found the dialyzer clearance of Foscarnet to be in the order of 89 ml/min. (Int J Artif Organs 2000; 23: 165–7)
PalestineA.G., PolisM.A., De SmetM.D.. A randomized, controlled trial of Foscarnet in the treatment of cytomegalovirus retinitis in patients with AIDS.Ann Intern Med1991; 115: 665–73.
2.
KlintmaimG., LonnqvistB., ObergB.. Intravenous Foscarnet for the treatment of severe cytomegalovirus infection in allograft recipients.Scand J Infect Dis1985; 17: 157–63.
3.
ReedE.C.. Treatment of cytomegalovirus pneumonia in transplant patients.Transplant Proc1991; 23: 8–12.
AweekaF.T., JacobsonM.A., Martin-MunleyS.. Effect of renal disease and hemodialysis on Foscarnet pharmacokinetics and dosing recommendations.J Acquir Immune Defic Synd1999; 20: 350–7.
6.
MacGregorR.R., GrazianiA.L., WeissR., GrunwaldJ.E., GambertoglioJ.G.. Successful Foscarnet therapy for cytomegalovirus retinitis in an AIDS patient undergoing hemodialyis: Rationale for empiric dosing and plasma level monitoring.J Infect Dis1991; 164: 785–7.
7.
DerayG., CacoubP., Le HoangP.. Foscarnet-induced acute renal failure and effectiveness of haemodialysis.Lancet1987; 2: 216.
8.
EmersonP.F., KeshaviahP.R., EbbenJ.P.. Pitfalls of in vivo dialyzer clearance measurement.Adv Ren Replace Ther1995; 2: 164–74.