Sage Journals: Discover world-class research

Abstract

Purpose

This study aimed to explore the effects of Baoyuan Yangxin Formula combined with acupuncture on angina symptoms and electrocardiographic myocardial ischemia indicators in patients with chest bi syndrome and heart pain of qi–yin deficiency with blood stasis.

Methods

A total of 98 patients who had chest bi syndrome and heart pain (qi–yin deficiency with blood stasis) treated during the periods of February 2021 to February 2022 were selected as the research objects, and by applying the random number table, we divided these patients into the control group which received acupuncture combined with conventional Western medicine treatment and the observation group which received Baoyuan Yangxin Formula combined therapy based on the control group. Between the two groups, we compared the electrocardiographic efficacy, clinical efficacy, and traditional Chinese medicine syndrome scores before and after the treatment. The occurrence of angina pectoris, electrocardiographic indicators, and hemodynamic indicators before and after the treatment were statistically analyzed between the two groups.

Results

Compared with the control group, the treatment's total effective rate in the observation group was higher (P < 0.05); and in both groups, TCM syndrome scores were significantly improved after the treatment. In comparison with those in the control group, the scores of chest tightness, chest pain, restlessness with insomnia, fatigue, shortness of breath, and spontaneous sweating in the observation group were lower (P < 0.05); after treatment, the visual analog scale (VAS) score in the observation group was lower than that in the control group, the frequency of angina attacks was less than that in the control group, and the duration was shorter than that in the control group (P < 0.05). Compared with the control group, the electrocardiographic efficacy in the observation group was better, and T-wave improvement after treatment was superior (P < 0.05). In the observation group, whole blood viscosity and plasma viscosity after treatment, as well as the fibrinogen levels, were lower than those in the control group (P < 0.05).

Conclusion

The integration of Baoyuan Yangxin Formula with acupuncture demonstrates a synergistic effect in managing chest bi syndrome and heart pain due to qi–yin deficiency with blood stasis. This combined approach not only significantly alleviates angina symptoms and improves electrocardiographic markers of myocardial ischemia but also positively influences hemodynamic parameters. These findings support its potential as a complementary therapeutic strategy in clinical practice, offering a holistic option that addresses both symptomatic relief and underlying pathological mechanisms.

Keywords

Baoyuan Yangxin Formula acupuncture combined therapy chest bi syndrome and heart pain qi–yin deficiency with blood stasis TCM syndrome electrocardiographic indicators

Get full access to this article

View all access options for this article.

References

Ahn

J. Y.

Chu

Leem

Yun

J. M.

(2024). Effectiveness and safety of traditional herbal medicine on cardiac arrhythmic condition: A systematic review and meta-analysis of randomized control clinical trial. Medicine (Baltimore), 103(23), e38441. https://doi.org/10.1097/MD.0000000000038441

Chinese Society of Cardiology, Editorial Board of Chinese Journal of Cardiology. (2007). Guidelines for the diagnosis and treatment of chronic stable angina pectoris. Chinese Journal of Cardiology, 35(3), 195–206. https://doi.org/10.3760/j.issn:0253-3758.2007.03.002

Chiarotto

Maxwell

L. J.

Ostelo

R. W.

Boers

Tugwell

Terwee

C. B.

(2019). Measurement properties of visual analogue scale, numeric rating scale, and pain severity subscale of the brief pain inventory in patients with low back pain: A systematic review. Journal of Pain, 20(3), 245–263. https://doi.org/10.1016/j.jpain.2018.07.009

Cho

M. S.

Kang

D. Y.

Y. S.

Lee

C. H.

Choi

E. K.

Lee

J. H.

Kwon

C. H.

Park

G. M.

Park

H. W.

Park

K. H.

Park

K. M.

Hwang

Yoo

K. D.

Cho

Y. R.

Kim

Y. R.

Hwang

K. W.

Jin

E. S.

Kim

P. J.

Kim

K. H.

… Nam

G. B.

(2022). Edoxaban-based long-term antithrombotic therapy in patients with atrial fibrillation and stable coronary disease: Rationale and design of the randomized EPIC-CAD trial[J]. American Heart Journal, 247(5), 123–131. https://doi.org/10.1016/j.ahj.2022.01.014

Fan

Liu

Miao

Zhang

Yan

Bai

Chang

Wang

Bian

Zhou

(2021). Anti-inflammatory activity of the Tongmai Yangxin pill in the treatment of coronary heart disease is associated with estrogen receptor and NF-κB signaling pathway[J]. J Ethnopharmacol, 276(9), 11410. https://doi.org/10.1016/j.jep.2021.114106

Hongcai

Baohe

Boli

(2004). Evaluation of syndromes and therapeutic effects of new Chinese medicines. Traditional Chinese Drug Research and Clinical Pharmacology, 15(5), 365–368. https://doi.org/10.3321/j.issn.1003-9783.2004.05.024

Kun

Xiaolin

Wei

(2025). Effects of Xuefu Zhuyu decoction combined with meridian-based acupoint selection on angina pectoris and SAQ scores. Journal of Clinical and Experimental Medicine, 24(6), 584–588. https://doi.org/10.3969/j.issn.1671-4695.2025.06.007

Liping

(2022). Observation on the efficacy of adding warm acupuncture and Xuefu Zhuyu decoction to conventional therapy in the treatment of coronary heart disease angina pectoris. Guizhou Medical Journal, 46(3), 417–418. https://doi.org/10.3969/j.issn.1000-744X.2022.03.041

National Symposium on Coronary Heart Disease, revised trial version in 1973. (1974). Evaluation criteria for coronary heart disease angina pectoris and electrocardiographic efficacy. People’s Military Surgeon, 17(5), 62–62. No DOI.

10.

Qiuyue

Meihua

Ruyu

(2022). Observation on the therapeutic effect of Xinkang capsules in the treatment of chest bi and heart pain of qi–yin deficiency complicated with blood stasis. Modern Journal of Integrated Traditional Chinese and Western Medicine, 31(7), 960–963. https://doi.org/10.3969/j.issn.1008-8849.2022.07.020

11.

Shen

Qiu

Liu

Shu

Zhou

(2022). Clinical implications of nicorandil combined with trimetazidine in patients with coronary heart disease: A real-world observational study. Advances in Therapy, 39(1), 655–673. https://doi.org/10.1007/s12325-021-01987-1

12.

Wang

Fan

Zhang

She

Liu

Wei

Guo

(2023). Exploration of prescription patterns and academic experience of national famous TCM physician Wang Xingkuan in treating chest bi and heart pain based on data mining. Chinese Journal of Experimental Traditional Medical Formulae, 29(5), 204–215. https://doi.org/10.13422/j.cnki.syfjx.20221412

13.

Wang

J. Y.

Zhang

Liu

Gao

Y. M.

Sun

J. J.

Liu

X. M.

(2021). [Acupuncture combined with western medication in treatment of type 2 diabetes mellitus with angina pectoris of coronary heart disease: A randomized controlled study]. Zhongguo Zhen Jiu, 41(4), 371–375 (in Chinese). https://doi.org/10.13703/j.0255-2930.20200329-k0001

14.

Wagner

G. S.

Macfarlane

Wellens

Josephson

Gorgels

Mirvis

D. M.

Pahlm

Surawicz

Kligfield

Childers

Gettes

L. S.

Bailey

J. J.

Deal

B. J.

Gorgels

Hancock

E. W.

Kors

J. A.

Mason

J. W.

Okin

Rautaharju

P. M.

van Herpen

(2009). AHA/ACCF/HRS recommendations for the standardization and interpretation of the electrocardiogram: Part VI: Acute ischemia/infarction: A scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society. Endorsed by the International Society for Computerized Electrocardiology. J Journal of the American College of Cardiology, 53(11), 1003–1011. https://doi.org/10.1016/j.jacc.2008.12.016

15.

Yanru

Guofeng

Yuanyuan

(2023). Efficacy of buccal acupuncture combined with qi-regulating and bi-unblocking acupuncture in the treatment of unstable angina pectoris and its effects on blood lipid metabolism and cardiac function. Journal of Clinical Acupuncture and Moxibustion, 39(9), 23–28. https://doi.org/10.19917/j.cnki.1005-0779.023172

16.

Yingchang

Yashuai

(2022). Therapeutic effects and influence of nicorandil combined with salvianolate in patients with coronary heart disease angina pectoris. Shanxi Medical Journal, 51(24), 2837–2839. https://doi.org/10.3969/j.issn.0253-9926.2022.24.021

17.

Yuting

Yueming

Wei

(2022). Therapeutic effects of Tongbu Zongqi acupuncture combined with exercise rehabilitation on coronary heart disease angina pectoris and its influence on serum NO and ET levels. Sichuan Journal of Traditional Chinese Medicine, 40(2), 190–192. https://doi.org/10.3969/j.issn.1000-3649.2022.2.sczy202202056

18.

Zhang

Liu

. (2025). Mechanisms of Shen Yuan Pellet treatment of coronary atherosclerotic heart disease. Acta Chinese Medicine, 40(10), 2109–2115. https://doi.org/10.16368/j.issn 1674-8999.2025.10.331

Effects of Baoyuan Yangxin Formula Combined with Acupuncture on Angina Symptoms and Electrocardiographic Myocardial Ischemia Indicators in Patients with Chest Bi Syndrome and Heart Pain of Qi–Yin Deficiency with Blood Stasis

Abstract

Purpose

Methods

Results

Conclusion

Keywords

Get full access to this article

References