Abstract
Purpose:
In order to study the degree of reliability of the cancer positive response found by Bi-Digital O-Ring Test originally developed by Prof. Omura, Y. of New York, cancer positive tissues by Bi-Digital O-Ring Test were evaluated with standard histopathological examination.
Materials & Methods:
327 patients (136 males, 191 females, ranging from 21-87 years old who visited Simotsuura Hospital Out-Patient Clinic, Kurume, Japan fora general check-up for a period of about 28 months after April, 1995) who were found to have cancer positive response by Bi-Digital O-Ring Test in the colon. On these patients, a total of 546 O-Ring Test cancer positive areas were examined. Cancer screening was made using Omura’s method of detecting pre-cancer or cancer (discovered in 1988-1989), which looks for the co-existence of a strong positive for Oncogene C-fos Ab2, Integrin α 5 β 1, Mercury & virus and disappearance (marked reduction) of acethylcholine. The exact location of the positive areas were mapped on the body surface. Subsequently, standard laboratory tests were performed on these patients with Barium enema, Optic fiber evaluation of the colon, and microscopic evaluation of pathological tissues. We divided patients into two groups; A group those who were diagnosed by Bi-Digital O-Ring Test and optic fiber evaluation by the same physician and B group those who were diagnosed by the physicians of different affiliations.
Results:
Number of cancer positive areas of A group (same physician who diagnosed by Bi-Digital O-Ring Test and optic fiber evaluation) was 455 locations which satisfied the coexistence of the 5 parameters for pre-cancer or cancer among 281 cases (114 males and 167 females); that of B group( physicians from different affiliations diagnosed by optic fiber evaluation) was 91 locations among 46 cases (22 males and 24 females).
Among the Bi-Digital O-Ring Test cancer positive areas, 68.5% of A group and 67% of B group agreed with standard laboratory tests.
Patho-histological examination results were as follows: a) Adenocarcinoma of the colon: 6 locations (1.9% of all the O-Ring positive areas) b) Polyp due to adenoma of the colon: 157 locations (50%) c) Hyperplastic polyp: 114 locations (36.5%) d) Inflammatory polyp: 31 locations (10% ) e) Erythema: 5 locations (1.6%).f) Carcinoid: 2 locations(0.6%). Together with polyp due to adenoma, 165 locations were correlated (52.2% ).
Discussion:
In O-Ring Test cancer positive areas, protruding pathological changes were discovered in high frequencies diagnosed by optic fiber evaluation by physicians without knowing the result of the diagnosis by the Bi-Digital O-Ring Test, but the detection of the actual cancer itself was of a small percentage. However, if polyp due to adenoma is considered as a pre-cancer state, detection rate of pre-cancer is more than 50%. This suggests that some of the tissues presently considered to be benign and have nothing to do with pre- cancer or cancer may in reality be pre-cancer itself. In order to differentiate such a subtle point, further research for the refinement of the necessary conditions for differential diagnosis is needed. This study indicated that the Bi-Digital O-Ring Test is very useful, powerful diagnostic tool for the screening of cancer and pre-cancer tissue and so every physician should take advantage of it, since there are no better simple, safe, and economical methods which have as high a detection rate as the Bi-Digital O-Ring Test cancer screening method.
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