Platelet function in vitro and in vivo (ADP-induced platelet aggregation, circulating platelet aggregates, β-thromboglobulin plasma levels) has been studied in children with common migraine, in headache-free intervals. Migraine patients demonstrated increased circulating platelet aggregates when compared with controls. Moreover, two of ten patients had pathological β-thromboglobulin levels. These data indicate that in some children with migraine there is an abnormality of platelet function during headache-free periods.
BilleB. Migraine in school children. Acta Paediatr [suppl 136]1962;51:14–151.
2.
ValquistB. Migraine in children. Int Arch Allergy1955;7:348–55.
3.
PrenskyALSommerD. Diagnosis and treatment of migraine in children. Neurology1979;29:506–10.
4.
PaulsonGW. Migraine headaches in children. Pediatr Nurs1980;6:41–2.
5.
HiltonBPCumingsJN. An assessment of platelet aggregation induced by 5-hydroxytryptamine. J Clin Path1971;24:250–8.
6.
KalendowskyZAustinJH. Complicated migraine. Its association with increased platelet aggregability and abnormal plasma coagulation factors. Headache1975;15:8–35.
7.
CouchJRHassaneinRS. Platelet aggregability in migraine. Neurology1977;27:843–8.
8.
HaningtonEJonesRJAmessJALWachowiczB. Migraine: a platelet disorder. Lancet1981;2:720–3.
9.
D'AndreaGToldoMCananziAFerro-MiloneF. Study of platelet activation in migraine: control by low doses of aspirin. Stroke1984;15:271–5.
10.
HaningtonE. Migraine: a blood disorder. Lancet1978;2:501–3.
11.
BornGVRCrossMJ. The aggregation of blood platelets. J Physiol (Lond)1963;164:178–95.
12.
WuKKHoakJC. A new method for the quantitative detection of platelet aggregates in patients with arterial insufficiency. Lancet1974;2:924–6.
13.
BarolinGS. Headache in children. In: CritchleyM eds Advances in neurology. New York: Raven Press, 1982;33:183–98.
14.
SicuteriF. Headache: disruption of pain modulation. In: BonicaJJAlbe-FessardD eds Advances in pain research and therapy. New York: Raven Press, 1976;1:871–80.
