A 15-year-old female survived a total of 65 minutes cardiac arrest following ingestion of verapamil and selective serotonin re-uptake inhibitors. We consider that the lack of neurological damage, despite evidence of significant renal and myocardial injury, may be related to the possible neuroprotective effect of a large dose of verapamil
ClintonJ.E., McGillJ., IrwinG., PetersonG., LiljaG.P., RuizE.Cardiac arrest under age 40: etiology and prognosis. Ann Emerg Med1984; 13: 1011–1015.
3.
MartinT.G.Serotonin syndrome. Ann Emerg Med1996; 28: 520–526.
4.
RosanskyS.Verapamil toxicity—treatment with hemoper-fusion. Ann Intern Med1991; 114: 340–341.
5.
HoferC.A., SmithJ.K., TenholderM.F.Verapamil intoxication: A literature review of overdoses and discussion of therapeutic options. Am J Med1993; 95: 431–438.
6.
BuckleyN.A., WhyteI.M., DawsonA.H.Overdose with calcium channel blockers. Br Med J1994; 308: 1639.
7.
DoyonS., RobertsJ.R.The use of glucagon in a case of calcium channel blocker overdose. Ann Emerg Med.1993; 22: 1229–1233.
8.
Ter WeeP.M., Kremer HovingaT.K., UgesD.R.A., van der GeestS.4-aminopyridine and haemodialysis in the treatment of verapamil intoxication. Hum Toxicol1985; 4: 327–329.
9.
CorkeronM.A., van HeerdenP.V., NewmanM.A.J., DusciL.Extracorporeal circulatory support in a near-fatal flecainide overdose. Anaesth Intensive Care1999; 27: 405–408.
10.
WatlingS.M., CrainJ.L., EdwardsT.D., StillerR.A.Verapamil overdose: case report and review of the literature. Ann Pharmacother1992; 26: 1373–1378.
11.
SternbachH.Fluoxetine-associated potentiation of calcium-channel blockers. J Clin Psychopharmacol1991; 11: 390.
SteingrubJ.S., MundtD.J.Blood glucose and neurologic outcome with global brain ischaemia. Crit Care Med1996; 24: 802–806.
14.
LongstrethW.T.Jr., DiehrP., CobbL.A., HansonR.W., BlairA.D.Neurologic outcome and blood glucose levels during out-of-hospital cardiopulmonary resuscitation. Neurology1986; 36: 1186–1191.
15.
ModestV.E., ButterworthJFIV. Effect of pH and lidocaine on β-adrenergic receptor binding. Interaction during resuscitation? Chest1995; 108: 1373–1379.
16.
SteenP.A., GisvoldS.E., MildeJ.H.. Nimodipine improves outcome when given after complete cerebral ischaemia in primates. Anesthesiology1985; 62: 406–414.
17.
ZapaterP., MorenoJ., HorgaJ.F.Neuroprotection by the novel calcium antagonist PCA50938, nimodipine and flunarizine, in gerbil global brain ischaemia. Brain Res1997; 772: 57–62.
18.
FleischerJ.E., NakakimuraK., DrummondJ.C., SchellerM.S., ZornowM.H., GrafeM.R., ShapiroH.M.Effects of levemopamil on neurological and histologic outcome after cardiac arrest in cats. Crit Care Med1992; 20: 126–134.
19.
GelmersH.J., GorterK., DE WeerdtC.J., WiezerH.J.A.A controlled trial of nimodipine in acute ischemic stroke. N Engl J Med1988; 318: 203–207.
20.
RoineR.O., KasteM., KinnunenA., NikkiP., SarnaS., KajasteS.Nimodipine after resuscitation from out-of-hospital ventricular fibrillation. A placebo-controlled, double-blind, randomized trial. JAMA1990; 264: 3171–3177.
21.
WaxmanA.B., WhiteK.P., TrawickD.R.Electromechanical dissociation following verapamil and propranolol ingestion: A physiologic profile. Cardiology1997; 88: 478–481.