Xenon has many of the properties of the ideal anaesthetic agent and has been proposed as a suitable replacement for nitrous oxide in routine clinical anaesthesia. Xenon, krypton and argon are chemically inert under most circumstances, yet all have anaesthetic properties. Xenon is of particular interest because it is the only ‘inert’ gas which is an anaesthetic under normobaric conditions. Because of this property, xenon has an important place in the history of the development of theories of anaesthetic action and of concepts such as MAC. Cost is likely to be a major impediment to the regular use of xenon.
BoomsmaF., RupnehtJ., Man in ‘t VeldA.J.Haemodynamic and neurohumoral effects of xenon anaesthesia. Anaesthesia1990; 45: 273–278.
2.
LachmannB., ArmbrusterS., SchairerW.Safety and efficacy of xenon in routine use as an inhalational anaesthetic. Lancet1990; 335: 1413–1415.
3.
StewardA., AllottP.R., CowleA.L., MapelsonW.W.Solubility coefficients for inhaled anaesthetics for water, oil and biological media. Br J Anaesth1973; 45: 282–293.
4.
LaneG.A., NahrwoldM.L., TaitA.R.Nitrous oxide is teratogenic: xenon is not! (abstract). Anesthesiology1978; 51: S260.
5.
CullenS.C., GrossE.G.The anesthetic properties of xenon in animals and human beings, with additional observations on krypton. Science1951; 113: 580–582.
6.
CRC Handbook of Chemistry and Physics.LideD.R. ed. Chapter 4: ‘The Elements’. 71st Ed. CRC Press, Boston1990.
7.
BenkeA.R., ThomsonR.M., MotleyE.P.The physiologic effects from breathing air at 4 atmospheres pressure. Am J Physiol1935; 112: 554–558.
8.
BenkeA.R., YarboughO.D.Respiratory resistance, oil-water solubility, and mental effects of argon, compared with helium and nitrogen. Am J Physiol1939; 126: 409–415.
9.
LawrenceJ.H., LoomisW.F., TobiasC.A., TurpinF.H.Preliminary observations on the narcotic effect of xenon with a review of values for solubilities of gases in water and oils. J Physiol1946; 105: 197–204.
BrakenA., BurnsT.H.S., NewlandD.S.A trial of xenon as a non-explosive anaesthetic. Anaesthesia1956; 11: 40–49.
13.
EgerE.I., BrandstaterB., SaidmanL.J., ReganM.J., SeveringhausJ.W., MunsonE.S.Equipotent alveolar concentrations of methoxyflurane, halothane, diethyl ether fluroxene, cyclopropane, xenon and nitrous oxide in the dog. Anesthesiology1965; 26: 771–777.
14.
DominoE.F., GottliebS.F., BrauerR.W., CullenS.C., FeatherstoneR.M.Effects of xenon at elevated pressures in the dog. Anesthesiology1964; 25: 43.
15.
CullenS.C., EgerE.I., CullenB.F., GregoryP.Observations on the anesthetic effect of the combination of xenon and halothane. Anesthesiology1969; 31: 305–309.
16.
PaulingL.A Molecular Theory of General Anesthesia. Science1961; 134(3471): 15–21.
