Intravascular haemolysis is a rare but serious complication of Clostridium perfringens sepsis. The outcome is usually fatal unless treatment is started early. We describe a case of survival after haemolysis and multiple organ failure in the setting of a ruptured liver abscess and sepsis caused by C. perfringens in an immunocompetent 58-year-old male.
DalyJ.J., HaeuslerM.N., HoganC.J., WoodE.M.Massive intravascular haemolysis with T-activation and disseminated intravascular coagulation due to clostridial sepsis.Br J Haematol2006; 134: 553.
KapoorJ.R., MonteiroB., TanoueL., SiegelM.D.Massive intravascular hemolysis and a rapidly fatal outcome.Chest2007; 132: 2016–2019.
4.
EgyedM., RajnicsP., KollarB., SinkoJ., ZsoldosE., RepaI.Severe hemolytic anemia and acute psychosis caused by Clostridium perfringens sepsis.Med Sci Monit2008; 14: CS13–16.
5.
McArthurH.L., DalalB.I., KollmannsbergerC.Intravascular hemolysis as a complication of clostridium perfringens sepsis.J Clin Oncol2006; 24: 2387–2388.
6.
EckelF., LerschC., HuberW., WeissW., BergerH., Schulte-FrohlindeE.Multimicrobial sepsis including Clostridium perfringens after chemoembolization of a single liver metastasis from common bile duct cancer.Digestion2000; 62: 208–212.
7.
RamsayA.M.The significance of Clostridium welchii in the cervical swab and blood-stream in postpartum and postabortum sepsis.J Obstet Gynaecol Br Emp1949; 56: 247–258.
KasperD.L., MadoffL.C.Chapter 135: Gas Gangrene and Other Clostridial Infections. In: FauciA.S., BraunwaldE., KasperD.L., HauserS.L., LongoD.L., JamesonJ.L., LoscalzoJ.Harrison's Principles of Internal Medicine,17th Ed.McGraw Hill2008.
10.
PunK.C., WehnerJ.H.Abdominal pain and massive intravascular hemolysis in a 47-year-old man.Chest1996; 110: 1353–1355.
11.
CuttingR., NgJ., Chan-LamD., ShepherdR., QureshiH.Fatal haemolysis secondary to infection with Clostridium perfringens.Scott Med J2007; 52: 56.
12.
JimenezM., SanzC., AlvarezA., PereiraA.Massive intravascular haemolysis in a patient with Clostridium perfringens sepsis.Vox Sang2002; 82: 214.
13.
BlancoM., FerreirosC.[Massive haemolysis by Clostridium perfringens: quick diagnosis in a patient with severe sepsis].Ann Biol Clin (Paris)2007; 65: 181–184.
14.
RubenbergM.L., BakerL.R., McBrideJ.A., SevittL.H., BrainM.C.Intravascular coagulation in a case of Clostridium perfringens septicaemia: treatment by exchange transfusion and heparin.Br Med J1967; 4: 271–274.
15.
MorganM.S., LytleJ., BrysonP.J.The place of hyperbaric oxygen in the treatment of gas gangrene.Br J Hosp Med1995; 53: 424–426.
16.
BushG.W., ClementsR.H., PhillipsM., KentR.B.Jr.Clostridium perfringens sepsis with intravascular hemolysis following laparoscopic cholecystectomy: a newly reported complication.Am Surg1996; 62: 326–327.
17.
KorhonenK.Hyperbaric oxygen therapy in acute necrotizing infections. With a special reference to the effects on tissue gas tensions.Ann Chir Gynaecol2000; 89(Suppl 214): 7–36.
18.
HirnM., NiinikoskiJ., LehtonenO.P.Effect of hyperbaric oxygen and surgery on experimental gas gangrene.Eur Surg Res1992; 24: 356–362.
KreidlK.O., GreenG.R., WrenS.M.Intravascular hemolysis from a Clostridium perfringens liver abscess.J Am Coll Surg2002; 194: 387.
21.
SasakiT., NanjoH., TakahashiM., SugiyamaT., OnoI., MasudaH.Non-traumatic gas gangrene in the abdomen: report of six autopsy cases.J Gastroenterol2000; 35: 382–390.
22.
SingerA.J., MigdalP.M., OkenJ.P., ChaleS.N., MollU.M.Clostridium perfringens septicemia with massive hemolysis in a patient with Hodgkin's lymphoma.Am J Emerg Med1997; 15: 152–154.
23.
BorregoD., Maria-TomeP., CascalesP., Garcia AguayoJ.M., Perez AmorosG., AbadA.[Massive intravascular hemolysis in septicemia caused by Clostridium perfringens].Sangre (Barc)1991; 36: 315–317.
