Lithium-induced diabetes insipidus occurs in up to one third of patients on long-term therapy. It usually manifests during the treatment course, often with preceding signs or symptoms. We wish to highlight a case in which diabetes insipidus developed many days after cessation of long-term lithium therapy. We seek to explain this delayed onset by a discussion of the molecular and genetic changes underlying the pathogenesis of lithium-induced nephrogenic diabetes insipidus.
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KwonT.H., LaursenU.H., MarplesD., MaunsbachA.B., KnepperM.A., FrokiaerJ.Altered expression of renal AQPs and Na(+) transporters in rats with lithium-induced NDI.Am J Physiol Renal Physiol2000; 279: F552–564.
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LaursenU.H., Pihakaski-MaunsbachK., KwonT.H., Ostergaard JensenE., NielsenS., MaunsbachA.B.Changes of rat kidney AQP2 and Na, K-ATPase mRNA expression in lithium-induced nephrogenic diabetes insipidus.Nephron Exp Nephrol2004; 97: e1–16.
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