Polyurethane Films with Antimicrobial Properties,Intended for the Development of Coatings Preventing Catheter-Associated Bloodstream Infections

Abstract

An investigation was made of the production and properties of a system based on polyurethane of grade Elastollan 1154 D (BASF, West Germany) (PU) containing antiseptic chlorhexidine (1,6-di-(p-chlorophenyl-guanido)-hexane) (CH), intended for the development of an antimicrobial coating for catheters. It was shown that the release of CH into water from PU films of 70 μm thickness occurs over a period of 70–190 h, depending on the quantity of CH introduced. The obtained data on the release of CH were correlated with data on the antimicrobial activity of films, assessed by the modified Kirby–Bauer test. For the series of obtained systems, antimicrobial activity against Staphylococcus aureus (golden staph) was retained for 15 days.

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