The distribution of viral antigen in various organs of four approximately 10-month-old castrated male Friesian cattle experimentally infected with a highly virulent strain of rinderpest virus was studied. A monoclonal antibody with genus-specific reactivity for morbilliviruses was applied in an indirect immunoperoxidase method performed on formalin-fixed, paraffin-embedded tissue sections. Rinderpest viral antigen was located mainly in the cytoplasm of the epithelial cells of the digestive, respiratory, and urinary tracts, as well as in the cells of endocrine glands (adrenal, thyroid) and exocrine glands (salivary glands, sebaceous glands, exocrine pancreas). Furthermore, different types of cells in lymphatic organs contained rinderpest viral antigen. In contrast to the documented results of studies carried out with other morbilliviruses, tissues of the central nervous system did not contain viral antigen. Various types of epithelial and lymphoreticular cells are the main targets of a virulent strain of rinderpest virus in vivo.
AdamsJMBairdCFilloyL;
Inclusion bodies in measles encephalitisJ Am Med Assoc195:
290–2981966.
2.
AgamanolisDPTanJSParkerDL:
Immunosuppressive measles encephalitis in a patient with a renal transplantArch Neurol36:
686–6901979.
3.
AppelMJG:
“Pathogenesis ol” canine distemperAm J Vet Res30:
1167–11821969.
4.
BergeonP:
Pestc bovine: richesse en virus pestique des tissus nerveux el de la moelle OStseuse de veaux attcinis des pestc bovine experimcntalcBull Soc Pathol Exot45:
148–1521952.
5.
BrownCCMarinerJCdanderHJ:
An immunohis-toehemical study of the pneumonia caused by pestc des pelils ruminants virusVet Pathol28:
166–1701991.
6.
BrownCCOlanderHJ:
Localization of rinderpest virus in bovine lymphoid tissue using immunohisiochcmis-tryProc Annu Meet Am Coll Vet Pathol42:
1901991.
7.
ItundaAAlsharADukesTWMyersDJDulacGCBeckerSAWE:
Experimental pesle des pclils ruminanls (goal plague) in goals and sheepCan J Vcl Res52:
46–521988.
8.
DomingoMVisaJPumarolaMMarcoAJFerrerLRabanalRKennedyS:
Pathologic and immunocyto-chcmical studies ormorbilli virus infection in striped dol-phins (Stene/ta coeruteoa/ba)Vet Pathol29:
1–101992.
9.
GalliumbiPJonssonLNilssonCWamwayiIIWafulaJS:
Immunohisiological localisation of rinderpest virus in formalin-fixed paraffin-embedded tissues from experimentally infected cattleJ Vcl Med R36:
261–2701989.
10.
GibbsEPJTaylorWPLawmanMJPBryantJ:
Classification of pcslc des pclits ruminanls virus as the fourth member of the genus MorbillhirmIntervirology11:
268–2741979.
11.
HarderTCMoenningVGreiscr-WilkcIBarrettTLiessB:
Analysis of antigenic differences between sixteen phocine distemper virus isolates and other morbil-liviruscsArch Virol118:
261–2681991.
12.
HigginsRJKrakowkaSMclzlcrAEKocstncrA:
Canine distemper virus-associated cardiac necrosis in the dogVcl Pathol18:
472–4861981.
13.
KennedySSmythJACushPFDuignanPFlattenMMcCulloughSJAllanGM:
Histopathologic and im-munocytochemical studies of distemper in sealsVcl Pathol26:
97–1031989.
14.
KennedySSmythJACushPFMcAliskcyMMcCulloughSJRimaBK:
Histopathologic and immu-nocylochcmicalstudicsofdistcmpcrin harbor porpoisesVet Pathol28:
1–71991.
15.
KimuraATosakaKNakaoT:
Measles rash 1 Light and electron microscopic study of skin eruptionsArch Virol47:
295–3071975.
OglcsbccMJKrakowkaSG:
The cellular stress response and intranuclear inclusion body formation by canine distemper virusProc Annu Meet Am Coll Vet Pathol42:
1241991.
22.
PlowrighlW:
Studies on the pathogenesis of rinderpest in experimental cattle II Proliferation of the virus in different tissues following intranasal infectionJ Hyg (Camb)62:
257–2811964.
RomeroCIIBarrettTEvansSAKitchingRPGershonPDBostockCBlackDN:
A single capripoxvirus recombinant vaccine for the protection of cattle against rinderpest and lumpy skin diseaseVaccine11:
737–7421993.
25.
RossiterPBJcsscttDM:
Detection of rinderpest virus antigens in vitro and in vivo by direct immunofluorescenceRes Vcl Sci33:
198–2041982.
26.
SahalM:
Kur/berichl: Berichl iiber die Rinderpest in derTurkci 1991/92 Dlsch Ticrar/llWochcnschr99:
349–3501992.
27.
ScottGR:
Rinderpest Adv Vet Sci9:
113–2241964.
28.
ScottGR:
Diagnosis of RinderpestFAO Agricultural StudiesRome Italy1967.
29.
ScotlGR:
Rinderpest ///; Infectious Diseases of Wild Mammals
cd DavisJWKarstadLHTrainerDO2nd ed,
pp 18–30Iowa State University PressAmes 1A1981.
30.
ScottGR:
Rinderpest' Virus Infections of Ruminanls
ed DinlcrZand MorcinB
pp 341–354ElsevierAmsterdam the Netherlands1990.
31.
TajimaMMotohashiTKtshiSNakamuraJ:
A comparative electron microscopic study on the morphogenesis of canine distemper and rinderpest virusesJpn J Vet Sci33:
1–101971.
32.
TajimaMUshijimaT:
The pathogenesis of rinderpest in the lymph nodes of cattleAm J Pathol62:
211–2351971.
33.
TaylorWP:
Epidemiology and control of rinderpestRev Sci Tech Offlnt Epi/oot5:
407–4101986.
34.
VandeveldeMKristcnscnB:
Observations on the distribution of canine distemper virus in the central nervous system of dogs with dcmyclinating encephalitisActa Ncuropathol40:
233–2361977.
35.
VisscrIKGKumarevVPOrvcllCDeVriesPBroedersHWJVan DeBiidiMWGGroenJTeppemaJSBurgerMCUyldehaagFGCMOstcrhausADME:
Comparison of two morbilliviruses isolated from seals during outbreaks of distemper in North West Europe and SiberiaArch Virol111:
149–1641990.
36.
YamanouchiK:
Comparative aspects of pathogenicity ofmcaslcs canine distemper and rinderpest virusesJpn J Med Sci Biol33:
41–661980.
37.
YamanouchiKInuiKSugimotoMAsanoKNishi-makiFKitchingRPTakamatsu11BarrettT:
Efficacy in cattle of recombinant vaccinia virus expressing the haemagglutimn gene of rinderpest virusVet Rcc132:
152–1561993.
38.
YamanouchiKKobuncFFukudaAHayamiMShi-shidoA:
Comparative immunofiuorcsccnt studies on measles canine distemper and rinderpest virusesArch Gcsamtc Virusforsch29:
90–1001970.
