Choriocarcinoma is one of the rarest ovarian tumors in any animal species. This paper describes the gross and microscopic appearance of seven such neoplasms in B6C3F1 mice. Mean age at death was 47 weeks. Tumors were described at necropsy as dark or hemorrhagic cystic lesions. On microscopic examination tumors were composed of hematocysts, intercellular hemorrhage, and cytotrophoblasts, syncytiotrophoblasts, and/or trophoblastic giant cells. Cytotrophoblasts, syncytiotrophoblasts, and occasional giant cells were present in three cases while the other four tumors contained only trophoblastic giant cells.
References
1.
BallV:
Le cancer de l'uterus chez les femelles domestiques.Revue Vet J Med Vet84:
72–78,
1932
2.
BergJWBaylorSM:
The epidemiologic pathology of ovarian cancer.Hum Pathol4:
537–547,
1973
3.
ItoHOzekiASekineTMuiraSHosokawaT:
Cell kinetic analysis of induced choriocarcinoma in rats.Cell Mol Biol26:
319–326,
1980
4.
KomuroN:
Experimental induction of chorionepithelioma in pregnant rats.Acta Obst Gynecol Jap23:
32–42,
1976
5.
KushimaKNodaKMakitaM:
Experimental production of chorionic tumor in rabbits.Tohoku J Exp Med (Japan)91:
209–214,
1967
6.
MajeedSKAlisonRHBoormanGAGopinathC:
Ovarian yolk sac carcinoma in mice.Vet Pathol23:
776–778,
1986
7.
Marin-PadillaMBenirschkeK:
Thalidomide induced alterations in the blastocyst and placenta of the armadillo, Dasypus novemcinctus mexicanus, including a choriocarcinoma.Am J Pathol43:
999–1016,
1963
8.
MiyamotoMNilsuwarnNAngsubhakornS:
Morphology of experimental chorionic tumors in rats.Acta Pathol Jap22:
343–352,
1972
9.
NicolasJFAvnerPGaillardJGuenetJLJakobHJacobF:
Cell lines derived from teratocarcinomas.Cancer Res36:
4224–4231,
1976
10.
RamseyEM:
The Placenta of Laboratory Animals and Man,
p. 134.
SAGE Publications,
New York,
1975
11.
RiserWH:
Chorioepithelioma of the uterus of a dog.J Am Vet Med Assoc96:
271–272,
1940
12.
RiserWH:
Chorioepithelioma of the bitch.J Am Vet Med Assoc100:
65–66,
1942
13.
RussellPPainterDM:
The pathological assessment of ovarian neoplasms V: the germ cell tumours.Pathology14:
47–72,
1982
14.
SchlotthauerCF:
Primary neoplasms in the genito-urinary system of dogs: a report often cases.J Am Vet Med Assoc95:
181–186,
1939
15.
ScullyRE:
Tumors of the Ovary and Maldeveloped Gonads,
pp. 243–245.
Armed Forces Institute of Pathology,
Washington,
1979
16.
ShintaniSGlassLEPageEW:
Studies of induced malignant tumors of placental and uterine origin in the rat.Am J Obstet Gynecol95:
550–558,
1966
17.
SquireRAGoodmanDGValerioMGFredricksonTStrandbergJDLevittMHLingemanCHHarshbargerJCDaweCJ:
Tumors.In:
Pathology of Laboratory Animals,
ed. BenirschkeKGarnerFMJonesTC,
pp. 1172–1182.
Springer-Verlag,
New York,
1978
18.
StevensLCVarnumDS:
The development of teratomas from parthenogenetically activated ovarian mouse eggs.Dev Biol37:
369–380,
1974
19.
TalermanA:
Germ cell tumors of the ovary.In:
Pathology of the Female Genital Tract,
ed. BlausteinA,
pp. 602–603,
625–627.
Springer-Verlag,
New York,
1982
20.
TeshimaSSakashitaSKikuchiYAizawaM:
Histogenesis of yolk sac carcinoma induced by fetectomy in the rat.Gann72:
524–530,
1981
21.
TeshimaSShimosatoYKoideTKurokiMKikuchiYAizawaM:
Transplantable choriocarcinoma of rats induced by fetectomy and its biological activities.Gann74:
205–212,
1983
