Gastric hyperplasia occurred more frequently among densely housed mice than mice housed singly, and crowding stress may have been implicated in this increased prevalence. Affected stomachs had striking increases in sulfomucin secretion when compared with unaffected gastric mucosa. The mucin changes suggested incomplete maturation of mucous cells in this condition and were similar to those reported in association with early neoplastic or pre-neoplastic lesions in the stomach of both man and rodents.
References
1.
BeattieD.:
Effect of drugs on rats exposed to cold-restraint stress.J Pharm Pharmacol29:
748–751,
1977
2.
BerensonM. M.SannellaJ.FrestonJ. W.:
Ménétrier's disease. Serial morphological, secretory, and serological observations.Gastroenterology70:
257–263,
1976
3.
BrocheriouC.BouchonP.-P.SqualliS.ChometteG.:
Gastrite hypertrophique géante de Ménétrier. Etude histochimique et ultrastructurale.Arch Anat Cytol Pathol24:
269–274,
1976
4.
ChvedoffM.ClarkeM. R.IrisarriE.FacciniJ. M.MonroA. M.:
Effects of housing conditions on food intake, body weight and spontaneous lesions in mice. A review of the literature and results of an 18-month study.Food Cosmet Toxicol18:
517–520,
1980
5.
CookR. W.WilliamsJ. F.:
Pathology of Taenia taeniaeformis infection in the rat: Gastrointestinal changes.J Comp Pathol91:
205–217,
1981
6.
CookR. W.WilliamsJ. F.LichtenbergerL. M.:
Hyperplastic gastropathy in the rat due to Taenia taeniaeformis infection: Parabiotic transfer and hypergastrinemia.Gastroenterology80:
728–734,
1981
7.
FilipeM. I.:
Mucins in the human gastrointestinal epithelium: A review.Invest Cell Pathol2:
195–216,
1979
8.
FlattR. E.HalvorsenJ. A.KempR. L.:
Hexamitis in a laboratory mouse colony.Lab Anim Sci28:
62–65,
1978
GislerR. H.:
Stress and the hormonal regulation of the immune response in mice.Psychother Psychosom23:
197–208,
1974
11.
GoldenbergM. M.:
Study of cold + restraint stress gastric lesions in spontaneously hypertensive, Wistar and Sprague-Dawley rats.Life Sci12:
519–527,
1973
12.
JassJ. R.FilipeM. I.:
Sulphomucins and precancerous lesions of the human stomach.Histopathology4:
271–279,
1980
13.
JubbK. V. F.KennedyP. C.:
Pathology of Domestic Animals,
2nd ed.,
pp. 74–81.
Academic Press,
New York,1970
14.
KojimaA.TaguchiO.NishizukaY.:
Experimental production of possible autoimmune gastritis followed by macrocytic anemia in athymic mice.Lab Invest42:
387–395,
1980
15.
LevR.SpicerS. S.:
Specific staining of sulphate groups with Alcian blue at low pH.J Histochem Cytochem12:
309,
1974
16.
OdashimaS.:
Tumours of the oral cavity, pharynx, oesophagus, and stomach. In:
Pathology of Tumours in Laboratory Animals,
ed. TurusovV. S.,
vol. 2,
pp. 147–154.
International Agency of Research on Cancer,
Lyon,1979
17.
PearseA. G. E.:
Histochemistry. Theoretical and Applied,
vol. 1,
pp. 659–660,
3rd ed.Churchill Livingstone,
Edinburgh,1968
18.
RobinsP. G.:
Ultrastructural observations on the pathogenesis of aspirin-induced gastric erosions.Br J Exp Pathol61:
497,
1980
19.
RowlattG.FranksL. M.SheriffM. U.Chester-manF. C.:
Naturally occurring tumors and other lesions of the digestive tract in untreated C57BL mice.JNCI43:
1353–1368,
1969
20.
SenayE. C.LevineR. J.:
Synergism between cold and restraint for rapid production of stress ulcers in rats.Proc Soc Exp Biol Med124:
1221–1223,
1967
21.
SheahanD. G.JervisH. R.:
Comparative histochemistry of gastrointestinal mucosubstances.Am J Anat146:
103–132,
1976
StewartH. L.AndervontH. B.:
Pathologic observations on the adenomatous lesion of the stomach in mice of strain 1.Arch Pathol26:
1009–1022,
1938
24.
StewartH. L.HareW. V.LorenzE.BennettJ. B.:
Adenocarcinoma and other lesions of the glandular stomach of mice following intramural injection of 20-methylcholanthrene.JNCI10:
359–360,
1969
25.
SuganumT.SuzukiS.TsuyamaS.MurataF.:
Mucosubstances of the rat gastric mucosa studied by means of several histochemical methods.Acta Histochem Cytochem14:
534–548,
1981
26.
SuzukiY.TaguchiO.KojimaA.MatsuyamaM.NishizukaY.:
Fine structure of giant hypertrophic gastritis developed in thymectomized mice.Lab Invest45:
209–217,
1981
27.
TsiftsisD.JassJ. R.FilipeM. I.WastellC.:
Altered patterns of mucin secretion in precancerous lesions induced in the glandular part of the rat stomach by the carcinogen N-methyl-N'-nitro-N-nitrosoguanidine.Invest Cell Pathol3:
399–408,
1980
