The ultrastructure of the hypothalamic-neurohypophysial system in dogs was shown to be similar to other mammalian species. Diabetes insipidus was manifested morphologically by vesiculation and loss of ribosomes from the endoplasmic reticulum and an inactive Golgi apparatus in the neurons of the supraoptic nucleus. Axons and axon-terminals within the pars nervosa were devoid of mature neurosecretory granules. The diabetes insipidus appeared to be the result of compression of neurons within the supraoptic nucleus by the slowly expanding adenohypophysial neoplasm which resulted in a diminished synthesis of transport protein.
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