The combination of thyroid cancer and secondary uremic hyperparathyroidism has thus far been reported in only 25 cases.
Methods
Here we report our experience of 19 patients with secondary hyperparathyroidism who underwent parathyroidectomy.
Results
Thyroid nodules were present in five patients (26.3%), including one with a benign nodule and four with papillary thyroid cancer (21.1%).
Conclusion
Our experience suggests that, in order to make a correct diagnosis, clinicians should consider the possibility of thyroid cancer in uremic patients with secondary hyperparathyroidism.
BushA., GabrielR.: Cancer in uremic patients.Clin. Nephrol., 22: 77–81, 1984.
2.
FavusM.J., SchneiderA.B., StachuraM.E.: Thyroid cancer occurring as a late consequence of head-and-neck irradiation: evaluation of 1056 patients.N. Engl. J. Med., 294: 1019–1025, 1976.
3.
HoriguchiT., IshikawaI., NakamuraM.: Studies on 10 cases of thyroid tumor associated with secondary hyperparathyroidism.Touseki Kaishi, 29: 103–107, 1996 (in Japanese).
MikiH., OshimoK., InoueH.: Thyroid carcinoma in patients with secondary hyperparathyroidism.J. Surg. Oncol., 49: 168–171, 1992.
8.
NasuE., EldarS., ShajrawiI.: Secondary hyperparathyroidism and nonmedullary thyroid cancer.Isr. J. Med. Sci., 31: 186–188, 1995.
9.
NishiyamaR.H., LudwigG.K., ThompsonN.W.: The prevalence of small papillary thyroid carcinomas in 100 consecutive necropsies in an American population.In: Radiation-associated thyroid carcinoma.De GrootL.J. (Ed.), pp. 123–135, Grune & Stratton, New York, 1977.
10.
OgburnP.L., BlackB.M.: Primary hyperparathyroidism and papillary adenocarcinoma of the thyroid: report of four cases.Proc. Staff Meet. Mayo Clin., 31: 295–298, 1956.
11.
PrinzR.A., PaloyanE., LawrenceA.M., PickelmanJ.R.: Radiation-associated hyperparathyroidism: a new syndrome.Surgery, 82: 296–300, 1977.
12.
ShishidoY.: A study of malignant tumors in long-term dialysis patients (the second report).28: 792–796, 1990 (in Japanese).
13.
Sitges-SerraA., CaralpsA., MasramonJ.: Carcinoma of the thyroid associated with uremic secondary hyperparathyroidism. Total parathyroidectomy with autotransplant of the parathyroid.Rev. Clin. Esp., 157: 443–444, 1980.
14.
SizemoreG.W., CarneyJ.A., HealthH.III: Epidemiology of medullary carcinoma of the thyroid gland: a 5-year experience (1971-1976).Surg. Clin. North. Am., 57: 633–645, 1977.
15.
SokalJ.E.: Occurrence of thyroid cancer.N. Engl. J. Med., 249: 393–397, 1953.
16.
TaylorS.: Calcium as a goitrogen.J. Endrocrinol. Metab., 14: 1412–1422, 1954.
17.
TisellL.-E., CarlssonS., LindbergS.: Autonomous hyperparathyroidism: a possible late complication of neck radiotherapy.Acta. Chir. Scand., 142: 367–373, 1976.
18.
UnoH., NishidaY., KobayashiK.: Minimal thyroid carcinoma associated with secondary hyperparathyroidism.Touseki Kaishi, 26: 1381–1385, 1993 (in Japanese).
19.
YamamotoY., MaedaT., IzumiK.: Occult papillary carcinoma of the thyroid.Cancer, 65: 1173–1179, 1990.
