A Polarographic study of oxigen was done in 57 rats inoculated with Walker 256 tumor and platinum electrode implanted in muscle and in tumor. The goal of the research was the study of oxygen in tumor before and after irradiation. Tumor growth caused a decrease in tumoral oxygen. Oxygen was always lower in the tumor than in the muscle. Radiotherapy with 2000 rad (but not with 1000 rad) increased oxygen in the tumor.
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References
1.
BergsjöP., EvansJ.C.: Oxygen tension of cervical carcinoma during the early phase of external irradiation.Scand. J. Clin. Lab. Invest., 27: 71–82, 1971.
2.
CaterD.B.: Oxygen tension in neoplastic tissues.Tumori, 50: 435–444, 1964.
3.
CaterD.B., PhillipsA.F., SilverI.A.: The measurement of oxydation-reduction potentials, pH, and oxygen tension in tumours.Proc. Roy. Soc. B., 146: 382–399, 1957.
4.
CaterD.B., SilverI.A.: Quantitative measurements of oxygen tension in normal tissue and in the tumours of patients before and after radiotherapy.Acta Radiol., 53: 233–256, 1959.
5.
DenekampJ., JoinerM.C.: The potential benefit from a perfect radiosensitizer and its dependence on reoxygenation.Br. J. Radiol., 55: 657–663, 1982.
6.
EhrlyA.M.: Determination of Tissue Oxygen Pressure in Patients.Pergamon Press, Oxford, 1983.
7.
EvansN.T.S., NaylorP.F.D.: The effect of oxygen breathing and radiotherapy upon the tissue oxygen tension of some human tumours.Br. J. Radiol., 36: 418–425, 1963.
GrayL.H.: Oxygenation in radiotherapy.I. Radiobiological considerations. Br. J. Radiol., 30: 403–406, 1957.
11.
GrayL.H., CongerA.D., EbertM., HornseyS., ScottO.C.A.: The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy.Br. J. Radiol., 26: 638–648, 1953.
12.
HájekJ.: A Course in Nonparametric Statistics.Holden-Day, San Francisco, 1969.
13.
LucchiariP.H., FeofiloffE.F., BoscardimA.T., BacilaM.: A technique for the determination of the available oxygen in living carp (Cyprinus carpio) muscle.Comp. Biochem. Physiol., 78A: 675–679, 1984.
14.
PappováN., SirackáE., VacekA., DurkovskyJ.: Oxygen tension and prediction of radiation response. Polarographic study in human breast cancer.Neoplasma, 29: 669–674, 1982.
15.
TrottK.R.: Experimental results and clinical implications of the four R's in fractionated radiotherapy.Radiother. Environ. Biophys., 20: 159–170, 1982.
16.
UrbachF.: Pathophysiology of malignancy: I - Tissue oxygen tension of benign and malignant tumours of the skin.Proc. Soc. Exp. Biol. Med., 92: 644–649, 1956.
17.
VasliS.: Post-ischemic polarography in human calf muscle.Acta Chir. Scand. Suppl., 315: 1–61, 1963.
