Trauma produced by amputation of a limb bearing the primary tumor influenced pulmonary metastases of the Carcinosarcoma of Walker 256 of the rat. This enhancement was present in 38% of the animals following the removal of a limb bearing the primary tumor; and in 29% of those in which the controlateral limb without tumor was amputated. A significant prolongation of the clotting time, an elevation of fibrinogen factor II and VII and a rapid consumption of factor VIII present soon after trauma may have been the parameter responsible for the increase of pulmonary metastases seen in this tudy.
Get full access to this article
View all access options for this article.
References
1.
AgostinoD., ClifftonE.E.: Anestetic effect on pulmonary metastases in rats. Development of metastases of Walker 256 carcinosarcoma.Arch. Surg., 88: 735–739, 1964.
2.
AgostinoD., ClifftonE.E.: Organ localization and the effect of trauma on the fate of circulating tumor cells.Cancer Res., 25: 1728–1732, 1965.
3.
AgostinoD., ClifftonE.E.: The growth and transplantability of the carcinosarcoma of Walker 256 in the ascitic form.Experientia, 24: 166–167, 1968.
4.
BergentezS.E., NilssonI.M.: Effect of trauma on coagulation and fibrinolysis in dogs.Acta Chir. Scand., 122: 21–27, 1961.
5.
BorgstromS., GelinL.E., ZederfeldtB.: The formation of vein thrombi following tissue injury. An experimental study in rabbits.Acta Chir. Scand. Supp., 247, 1959.
6.
FisherB., FisherE.R.: Effect of surgical trauma on the growth of experimental induced hepatic metastases.Ann. Surg., 150: 731–737, 1959.
7.
FreimanA.H., BangN.U., ClifftonE.E.: Studies on the production of intravascular thrombi and their treatment with fibrinolysin.Circ. Res., 8: 409–415, 1960.
8.
GaylordH.R., SimpsonB.T.: Effect of certain anesthetics and loss of blood upon growth of implanted mouse cancer.J. Cancer Res., 1: 379–381, 1916.
9.
GelinL.E., RudenstamC.M.: Trauma microcirculation and tumor spread.Yearbook of the Sweedish Cancer Soc., 4: 55–64, 1966.
10.
HardistyR.M., McPersonJ.C.: One-stage factor VIII (antihemopylic globulin) assay and its use on venous and capillary plasma.Thromb. Diat. Haemorrh., 7: 215–221, 1962.
11.
KinseyD.L.: Experimental study on preferential metastases.Cancer13: 674–676, 1960.
12.
IwasakiT.: Hystological and experimental observations on the destruction of tumor cells in the blood.J. Path. Bact., 20: 85–89, 1915.
13.
IvarsonL., RudenstamC.M.: Trauma dextran 40 and metastases formation after intravenous tumor cell injection in rats.Acta Chir. Scand., 142: 226–230, 1976.
14.
LangdellR.D., WagnerR.M., BrinkousK.M.: Effect of antihemophylic factor on one-stage clotting test. A presumptive test for hemphylia and a simple one-stage anti-hemphylic factor assay procedure.J. Lab. Clin. Med., 41: 637–647, 1953.
15.
LewisM.R., TrevinoE.: Experimental use of Amphenone in neutralizing the decreased resistence to inoculated cancer cells produced by stress. Cited by Cole: Dissemination of cancer. Prevention and therapy. Appleton Century Crofts Inc,1961.
16.
LewisR.L., ColeW.H.: Experimental increase of lung metastases after operative trauma (Amputation of a limb with tumor).AMA Arch. Surg., 77: 621–626, 1958.
LeeR.I., WhiteP.D.: A clinical study of the coagulation of blood.Am. J. Med., 145: 495–503, 1913.
19.
QuickH.S.: The physiology and pathology of hemostasis.Philadelphia Eds. Lea and Febiger, 1961.
20.
RudenstamC.M.: Experimental studies on trauma and metastases formation.Acta Chir. Scand. Suppl., 391, 1968.
21.
SapphirO.: The fate of carcinoma emboli in the lungs.Am. J. Pathol., 23: 245–249, 1947.
22.
SchattenW.E.: Growth of pulmonary metastases following the total removal of the primary leg tumor.Cancer, 11: 455–459, 1958.
23.
SealS.H.: Silicone flotation: Simple quantitative method for the isolation of free-floating cancer cells from the blood.Cancer, 12: 590–595, 1959.
24.
TyzzerE.E.: Factors in the production and growth of tumor metastases.J. Med. Res., 28: 309–312, 1913.
25.
WarrenS., GatesO.: The fate of intravenously injected tumor cells.Am. J. Cancer, 27: 485–489, 1936.
26.
WoodS.Jr.: Pathogenesis of metastases formation observed in vivo in the rabbit ear chamber.Arch. Pathol., 66: 550–556, 1958.
27.
WoodS.Jr., HoliokeE.O., YardleyH.: Mechanism of metastases production by blood born cancer cells.Canad. Cancer Conf., 4: 167–223, 1961.
28.
WoodS.Jr.: Experimental studies on the intravascular dissemination of ascitic V2 carcinosarcoma cells with reference to fibrinogen and fibrinolytic agents.Bull. Swiss Acad. Med., 20: 92–147, 1964.
