T and B lymphocyte populations were monitored in the peripheral blood of two long-term plateletpheresis donors. The studies showed minimal fluctuation of both populations compared to the normal controls. The evidence so far accumulated seems to indicate that long-term manual plateletpheresis has no appreciable effect on the level of the T and B cell population of the peripheral blood. Further studies are needed to evaluate larger donor pools.
Get full access to this article
View all access options for this article.
References
1.
CohenM. A., ObermanH.A.: Safety and long-term effects of plasmapheresis.Transfusion, 10: 58–66, 1970.
2.
DionigiR., ZontaA., AlbertarioF., GaleazziR., BellinzonaG.: Cyclic variation in the response of lymphocytes to phytohemagglutinin in healthy individual.Transplantation, 15: 550–557, 1973.
3.
DrewinkoB., SullivanM. T., MartinT.: Use of the cytocentrifuge in the diagnosis of leukemia.Cancer, 31: 1331–1336, 1973.
4.
HolmG., PatternD., MellstedtH., HedfiersF., BlothB.: Lymphocyte subpopulations in peripheral blood of healthy persons. Characterization by surface markers and lack of selection during purification.Clin. Exp. Immunol., 20: 443–457, 1975.
5.
KlimanA., CarboneP. P., GaydosL. A., FreiriechE. J.: Effects of intensive plasmapheresis on normal blood donors.Blood, 23: 647–656, 1964.
6.
LichtigerB., TrujilloJ. M.: T and B lymphocytes in peripheral blood in normal donors after prolonged plateletpheresis.Transfusion,16: 534, 1976.
7.
MendesN. F., MolnaiM. E. A., SilveriaN. P. A., GilbertsenR. B., MetzganR. S.: Technical aspects of the rosette tests used to detect human complement receptor (B) and sheep erythrocyte-binding (T) lymphocytes.J. Immunol., 111: 860–867, 1973.
8.
SalvaggioJ. P., ArquembourgP., BickersJ., BiceD.: The effect of prolonged plasmapheresis on immunoglobulins, other serum proteins, delayed hypersensitivity and phytohemagglutinin-induced lymphocyte transformation.Int. Arch. Allergy Appl. Immunol., 41: 883–894, 1971.
9.
ShanbromE., LundakR., WalfordR. L.: Long-term plasmapheresis effects on specific proteins.Transfusion, 12: 162–167, 1972.
10.
Technical Manual of Procedures of the American Association of Blood Banks.6th Edition.MillerW. V. (ed.), J. B. Lippincott Co., 1974.
11.
YuD. T. Y., PeterJ. B., PaulusH. E., NiesK.M.: Human lymphocyte subpopulations: Study of T and B cells and their density distribution.Clin. Immunol. Immunopathol., 2: 333–342, 1974.
12.
WHO/IARA-sponsored workshop on human B and T cells. Identification, enumeration, and isolation of B and T lymphocytes from human peripheral blood. Special technical report.Scand. J. Immunol.,3: 521–532, 1974.
