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Abstract

Italian

A cytokinetic analysis has been made of 5-day and of 10-day old murine 6C3HED ascites lymphosarcoma (Gardner) by using a growth curve, percentage of labeled mitoses curves, and continuous labeling curves. The doubling time increased from 36 h in the proliferative phase of growth to 252 h in the stationary phase. The slowing down of the growth rate was due to prolongation of the cell cycle time, with greatest extension in G₁ and increased cell loss. The measurement of the kinetic parameters made immediately after irradiation with a whole-body single dose of 3 Gy (300 rad) showed an increase in duration of the cell cycle in the 5-day-old tumor, while in the 10-day-old tumor the cell cycle time was decreased due to reduce length in the G₁ phase.

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Cytokinetic Analysis at Various Ages of an Ascites Tumor after Radiation

Abstract

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