The present possibilities of clinically evaluating cell-mediated immune potential using skin reactivity to microbial protein antigens (streptokinase-streptodornase; tuberculin; formalin-killed parotitis virus) together with a contact sensitized such as dinitrochlorobenzene are examined. A single evaluation index for the set of cutireactions is proposed and, as a practical example, the delayed hypersensitivity data based on intradermal and patch tests in 41 cases of primary malignant tumor of the ovary are reported. There is a definite correlation between immune impairment and cancer spread, with a survival prognosis value even in initial cases.
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References
1.
CatalonaW. J., TaylorP. T., RabsonA. S. e ChretienP. B.: A method for dinitrochlorobenzene contact sensitization.A clinicopathological study. New Eng. J. Med., 286: 399–402, 1972.
2.
CatalonaW. J., ChretienP. B.: Abnormalities of quantitative dinitrochlorobenzene sensitization in cancer patients: correlation with tumor stage and histology.Cancer, 31: 353–360, 1973.
3.
EilberF. R., MortonD. L.: Impaired immunologic reactivity and recurrence following cancer surgery.Cancer, 25: 362–367, 1970.
4.
GasparriF.: La terapia dei tumori maligni dell'ovaio. Ia relazione.Atti del 55° Congresso della Società Italiana di Ostetricia e Ginecologia, pp. 7, Firenze, 1973.
5.
JohnsonM. W., MaibachH. I., SalmonS. E.: Skin reacticity in patients with cancer. Impaired delayed hypersensitivity or faulty inflammatory respose?,New Eng. J. Med., 284: 1255–1256, 1971.
6.
KhooS. K., MackayE. V.: Relation of cell-mediated immunity in women with genital tract cancer to origin histology, clinical stage and subsequent behaviour of neoplasm.J. Obstet. Gynec. Brit. Comm.,81: 229, 1974.
7.
MortonD. L.: Immunotherapy of cancer. Present status and future potential.Cancer,30, 1647–1655, 1972.
8.
PeritiP.: Valutazione di alcuni parametri del potenziale immunitario in rapporto al trattamento dei tumori maligni primitivi dell'ovaio. Tavola Rotonda su: La terapia dei tumori maligni dell'ovaio (F. Gasparri).Atti del 55° Congresso della Società Italiana di Ostetricia e Ginecologia, pag. 313, Firenze, 1973.
9.
PeritiF., SeveriS., CattaneoA., Levi D'AnconaV., CiuffiM.: La chemioterapia nel trattamento dei tumori primitivi dell'ovaio; correlazione al 1° tema di relazione: La terapia dei tumori maligni dell'ovaio (F. Gasparri).Atti del 55° Congresso della Società Italiana di Ostetricia e Ginecologia, pag. 188, Firenze, 1973.
10.
SoloweyA. C., RapaportF. T.: Immunologic responses in cancer patients.Surg. Ginec. Obstet.,121, 756–760, 1965.
