The principles of tests for carcinogenicity are presented and discussed.
Get full access to this article
View all access options for this article.
References
1.
BerwaldY., and SachsL.: In vitro transformation of normal cells to tumor cells by carcinogenic hydrocarbons.J. Nat. Cancer Inst., 35: 641–661, 1965.
2.
British Committee on Medical and Nutritional Aspects of Food Policy:Carcinogenic risks in food additives and pesticides.Mth. Bull. Minist. Hlth Lab. Serv., 19: 108–112, 1960.
3.
Della PortaG.: Some aspects of medical drug testing for carcinogenic activity. In: TruhautR. (ed.): Potential carcinogenic hazards from drugs.U.I.C.C. Monogr. Series, vol. 7, pag. 33–47, 1967.
4.
DomskyI.I., LijinskyW., SpencerK., and ShubikP.: Rate of metabolism of 9,10-dimetyl-1,2-benzanthracene in newborn and adult mice.Proc. Soc. Exp. Biol. Med., 113: 110–112, 1963.
5.
DruckreyH., PreussmannR., IvankovicS., und SchmählD.: Organotrope carcinogene Wirkungen bei 65 werschiedenen N-Nitroso-Verbidungen an BD-Ratten.Z. Krebsforsch., 69: 103–201, 1967.
6.
HueperW. C., and WolfeH. D.: Experimental production of aniline tumours of the bladder in dogs.Amer. J. Path., 13: 656–657, 1937.
7.
Joint FAO/WHO Expert Committee on Food Additives:Evaluation of the carcinogenic hazards of food additives. Fifth Report W.H.O. Techn. Rep. Series No. 220, Geneva, 1961.
8.
MirvishS., CividalliG., and BerenblumI.: Slow elimination of urethan in relation to its high carcinogenicity in newborn mice.Proc. Soc. Exp. Biol. Med., 116: 265–268, 1964.
9.
PietraG., SpencerK., and ShubikP.: Response of newly born mice to a chemical carcinogen.Nature, 183: 1689, 1959.
10.
ShubikP., and SicéJ.: Chemical carcinogenesis as chronic toxicity test.Cancer Res., 16: 728–742, 1956.
11.
Subcommittee on Carcinogenesis, Food Protection Committee, Food and Nutrition Board, National Academy of Sciences - National Research Council:Problems in the evaluation of carcinogenic hazards from use of food additives.Cancer Res., 21: 429–456, 1961.
12.
TannenbaumA., and SilverstoneH.: Urethan (ethyl carbamate) as a multipotential carcinogen.Cancer Res., 18: 1225–1231, 1958.