Abstract
Immunological investigations in 4 multiple myelomas with bone lesions, in 1 extraosseus myeloma, and in 1 reticulum-cell sarcoma with areas of plasma cellular transformation are described. Serum proteins were studied with immunodiffusion, immunoelectrophoresis and sedimentation constant. All identified serum paraproteins in the myeloma patients appeared to be of the IgG type, but with different electrophoretic mobility. Three cases were classified as «slow», one as «fast» and one as «intermediate» type. In the patient with reticulum-cell sarcoma alterations of the antigenic properties of the IgG immunoglobulins were present and they were compatible with the presence of a paraprotein. The immunoelectrophoretic pattern as well as the quantitative determination with immunoplates of the immunoglobulins yielded results almost directly proportional to the percentage of plasmacells detected through bone marrow aspiration and to the extent of the disease.
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