A crystalline substance with marked antimitotic activity on several biological systems (mitoses of ascites S 180, of the megaloblasts of chick embryo, of the tips of wheat radicles) has been isolated from the bulbs of several varieties of Narcissus and named Narciclasine. After reference to the tests that led to its discovery and isolation and to the work of others in the same field, the method of isolation is described together with the physical and chemical properties of the substance (identification, chromatographic behavior, UV, IR and fluorescence). The structural formula, established on the basis of work reported elsewhere, is given.
Get full access to this article
View all access options for this article.
References
1.
CeriottiG.: Narciclasine: an antimitotic substance from Narcissus bulbs. Nature, 213: 595–596, 1967.
2.
CeriottiG.: Azione della narciclasina sulle mitosi delle cellule del Sarcoma 180 ascite. Tumori, 1967 (in stampa).
3.
CeriottiG.: Azione della nareiclasina sulle mitosi delle cellule del meristema apicale delle radichette di frumento. Ann. Botanica, 1967 (in stampa).
4.
CeriottiG.: Studio sull'azione citotossica di estratti vegetali. Ann. Botanica, 28: 111–124, 1964.
5.
CeriottiG.: Studio di sostanze anticrescita di origine vegetale. 1) Metodo di valutazione quantitativa della attività anticrescita. Giorn. Botan. Ital., 73: 139–144, 1965.
6.
CeriottiG.: Alcune considerazioni sulla metodologia per la ricerca di sostanze potenzialmente antitumorali in mescolanze complesse di origine naturale. (in corso di stampa sul volume commemorativo del IV centenario del collegio Ghislieri di Pavia).
7.
CeriottiG.: A simple paper chromatographic technique. Nature, 175: 797–799, 1955.
8.
FitzgeraldD. B., HartwellJ. L., and LeiterF.: Tumor damaging activity in plant families showing antimalarial activity: amaryllidacee. J. Nat. Cancer Inst., 20: 763–774, 1958.
9.
MyamuraS.: A determination method for anticancer action of antibiotics by agar plate diffusion technique. Antibiot. Chemother., 6: 280–282, 1956.
10.
PiozziF., FugantiC., MandelliR., and CeriottiG.: On the structure of Narciclasine. Comunicazione al IV Symposium IUPAC Stockholm, 30 giugno 1966.
11.
PiozziF.: The structure of the new antimitotic narciclasine. Tetrahedron, 1967 (in stampa).
