Abstract
The author reports on the results of a study by his School on the relations between procoagulants and anticoagulants on the one hand and experimental carcinogenesis on the other. The antifibrinolytic or procoagulant substances used (epsilonaminocaproic acid, trasylol and thromboplastin) all shortened the latent period of some experimental tumors and the survival time of the animals. The anticoagulant used (laminarin) exerted no statistically significant effect on either onset or growth of 3:4-benzpyrene sarcomas but, unexpectedly, exerted an accelerating effect on the onset and growth of a transplantable rat tumor: IRE reticulosarcoma, whether solid or ascitic. A brief critical review of the results follows.
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