The results of a study carried out on 47 nipple secretion obtained from 156 patients with various diseases of the breast are presented. A good correlation between the cytological diagnosis, established following the Saphir's classification, and the histopathological diagnosis was found, either for benign or malignant diseases. Early cytological diagnoses of 2 intraductal carcinomas with initial Paget's disease of the nipple and one fibroadenoma with initial carcinomatous evolution, are reported. The usefulness of the method as a routine examination is confirmed.
Get full access to this article
View all access options for this article.
References
1.
AdairF. E.: Sanguineous discharge from nipple and its significance in relation to cancer of breast; study based on 108 cases.Ann. Surg., 81: 197–209, 1930.
2.
AxelrodH.: Nipple discharge.Am. J. Surg., 87: 247–250, 1954.
3.
CentonzeM. e GiammariaG.: Il ruolo della citologia nella diagnosi precoce del carcinoma della mammella.Atti Soc. Reg. Ost. Ginec., 12: 26–27, 1963.
4.
CheatleG. L. and CutlerM.: Tumours of the breast; their pathology, symptoms and treatment.E. Arnold & Co., London, 1931.
5.
DeaverJ. B. and Mc FarlandJ.: The breast; its anomalies, its diseases and their treatment. Pag. 535, Blakiston & Son, Philadelphia, 1917.
6.
EisenM. J. and TaftR. H.: Cytological diagnosis of mammary cancer associated with incipient Paget's disease of the nipple.Cancer, 4: 150–153, 1951.
7.
GeschickterC. F.: Diseases of the breast; diagnosis, pathology, treatment.J. B. Lippincott, Philadelphia, 1943.
8.
GiardiniR. G. y De PescettiN. C.: El estudio citologico del derrame mamilar en el diagnostico del carcinoma mamario.Sem. Med. (B.-Air.), 122: 1378–1379, 1963.
9.
HaagensenC. D.: Disease of the breast.W. B. Saunders Co., Philadelphia, 1956.
10.
JacksonD. and SeveranceA. O.: Cytological study of nipple secretions. An aid in the diagnosis of breast lesions.Texas State J. Med., 41: 512–514, 1946.
11.
JacksonD.ToddD. A. and GorsuchP. L.: Study of breast secretion for detection of intramammary pathologic change and of silent papilloma.J. Int. Coll. Surg., 15: 552–568, 1951.
12.
JacobsonB. D.: Early diagnosis of carcinoma of the breast by cytologic technique with report of one case.New Jersey M.S.J., 47: 337–338, 1950.
13.
KilgoreA. R.FlemingR. and RamosM. M.: The incidence of cancer with nipple discharge and risk of cancer in the presence of papillary disease of the breast.Surg. Gynec. Obst., 96: 649–660, 1953.
14.
KjellgrenO.: The cytologic diagnosis of cancer of the breast.Acta Cytol., 8: 216–223, 1964.
15.
NathanM.: Diagnostic précoce d'un néoplasme du sein par l'examen histologique de son suintement hémorragique.Clinique, Paris, 60: 38–39, 1914.
16.
PapanicolaouG. N.HolmquistD. G.BaderG. M. and FalkE. A.: Exfoliative cytology of human mammary gland and its value in diagnosis of cancer and other disease of breast.Cancer, 11: 377–409, 1958.
17.
SaphirO.: Cytologic examination of breast secretions.Am. J. Clin. Path., 20: 1001–1010, 1950.
