Abstract
The activity of some vegetal auxins in animal biology has been experimentally studied. A cyto- and mitokinetic action of Kinetine (6-furfurylaminopurine) was demonstrated on cells of sarcoma 180 of the rat, either by direct application or by action through the host organism.
Another auxin, the indolacetic acid, was found to stimulate the proliferation of vegetal and animal cells, and to increment their mitokinetic activity. These phenomena seem to be enhanced by the association indolacetic acid-Kinetine.
Researches carried out on normal albino mice parenterally treated with solutions of indolacetic acid alone, and associated with Kinetine, showed absence of acute and chronic toxicity, except for a certain degree of liver impairment due to the action of indolacetic acid. No influence was noted on the mitokinetic activity. on liver tissue, and on the cutaneous germinative layer. Similarly, the DNA synthesis in the liver tissue of animals treated with the tested auxins, appeared to be uninfluenced.
In a series of albino mice inoculated with 180 ascites sarcoma, and contemporaneously treated with indolacetic acid, and indolacetic acid + Kinetine (endoperitoneal or subcutaneous route), a marked stimulation of the initial tumour development was observed, with increase of ascites and stimulation of cytokinetic and mitokinetic activity of tumour cells. This influence was more marked following endoperitoneal administration. The association of the auxins did not seem to enhance their natural activities.
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