Abstract
Three cases of atypical plasmocytoma are discussed. A alpha-2 globulinic plasmocytoma, with absence of the characteristic radiological skeletel lesions, with many plasmacells in the bone marrow and a significant electrophoretic pattern only in the days preceding death; a beta-gamma globulinic plasmocytoma, which had begun with a symptomatology of sudden lumbar sciatica, without Bence-Jones protein and with a high percentage of plasmacells in the bone marrow; a case with acute, feverish onset, with skin infiltrations at the base of the neck, bone alterations demonstrable only in the final stage of the disease and presence of many plasmacells in the bon marrow. In these cases the diagnosis was possible because of two characteristics: the presence of plasmacells in the bone marrow smear and the disproteinemia. It is started that the frequency of atypical plasmocytomas is greater than commonly believed, and the necessity of systemic biopsic, electrophoretic and radiographic investigations in all suspect cases is underlined.
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