Azione Tossica Delle Diverse Frazioni Endocellulari Del Sarcoma Galliera Iniettate Nel Coniglio a Scopo Immunizzante

Abstract

6 groups of rabbits have been submitted to immunizing treatment with mitochondria from rat liver or with horse serum (controls), and with mitochondria, nuclei and supernatant from Galliera sarcoma. The doses of antigen were equivalent as total nitrogen, and the experimental conditions were the same for all animals.

Whereas normal endocellular fractions, horse serum and supernatant from Galliera sarcoma did not give significant results, the tumour mitochondria and nuclei were demonstrated to exert a very high toxic action in the rabbit, causing, in particular, a diminution of total proteins, and especially of globulins.

Following the treatment with the antigens, two different immunitary reactions have been observed, one of which was characterized by an increase in total nitrogen and globulins (especially beta-2 and gamma), and the other by a decrease of the same substances.