Spontaneous regression of small basal cell carcinoma has been reported. For giant basal cell carcinoma, however, no spontaneous regression has been described to date.
Case report
We present a patient with two independent giant basal cell carcinomas over the left clavicle and the lower back, measuring 7 × 12 cm and 18 × 20 cm, respectively. Both tumors were excised incompletely (R2) and the patient refused follow-up resections. After 52 and 16 months, respectively, no signs of recurrence were observed.
Conclusion
Incompletely excised giant basal cell carcinomas can regress spontaneously. A watch-and-wait approach after incomplete resection may be pragmatic to avoid mutilating follow-up resections in patients refusing further surgery.
LorenziniM., GattiS., GiannitrapaniA.: Giant basal cell carcinoma of the thoracic wall: a case report and review of the literature. Br J Plast Surg, 58(7): 1007–1010, 2005.
2.
HirschsteinerO., MaiwaldG., BaldaB.R.: Guess what! Diagnosis: Extended ulcerating metatypical basal cell carcinoma (BCC) with soft tissue and bone destruction. Eur J Dermatol, 10(4): 315–316, 2000.
3.
KoeppeT., KuipersT., HaugM., GreulichM., GubischW.: Single-stage defect repair with latissimus dorsi free flap after extensive resection of terebrant ulcer of the head: three case reports. Microsurgery, 21(7): 333–339, 2001.
4.
SonntagM., ReifenbergerJ., MegahedM., SchulteK.W.: [Ulcus terebrans. Therapy options and their limits] Ulcus terebrans. Therapiemoglichkeiten und ihre Grenzen. Hautarzt, 55(10): 983–985, 2004.
MainellaM., MajewskiW.T., LatkovichP., MichaelsB.M.: Two giant basal cell carcinomas presenting simultaneously in the same patient, one resulting in lower extremity limb loss. Ann Plast Surg, 41: 444–447, 1998.
16.
BianchiniR., WolterM.: Fatal outcome in a metatypical, giant, “horrifying” basal cell carcinoma. J Dermatol Surg Oncol, 13: 556–557, 1987.
17.
D'HermiesF., BarracoP., ElmalehC., Garnier-FavreA., LefrancD., PouliquenY.: [Giant basocellular carcinoma of the eyelid] Carcinome baso-cellulaire geant de la paupiere. J Fr Ophtalmol, 12: 240–243, 1989.
18.
BettiR., InselviniE., MoneghiniL., CrostiC.: Giant basal cell carcinomas: report of four cases and considerations. J Dermatol, 24: 317–321, 1997.
MoussalaM., Behar-CohenF., D'HermiesF., BengonoG., RenardG.: [Giant basal cell carcinoma of the eyelid in a black patient from Cameroon] Carcinome baso-cellulaire geant de la paupiere chez une patiente noire Camerounaise. J Fr Ophtalmol, 23(6): 595–598, 2000.
21.
ShermanJ.E., TalmorM.: Slow progression and sequential documentation of a giant basal cell carcinoma of the face. Surgery, 130(1): 90–92, 2001.
22.
TakemotoS., FukamizuH., YamanakaK., NakayamaT., KoraY., MinetaH.: Giant basal cell carcinoma: improvement in the quality of life after extensive resection. Scand J Plast Reconstr Surg Hand Surg, 37(3): 181–185, 2003.
23.
SchwartzR.A., De JagerR.L., JannigerC.K., LambertW.C.: Giant basal cell carcinoma with metastases and myelophthisic anemia. J Surg Oncol, 33: 223–226, 1986.
24.
GoringH.D., RathF.W., ZiemerA., PanznerM.: [Fatal course of basalioma terebrans caused by brain abscess with brain compression and hemorrhagic anemia] Todlicher Verlauf eines Basalioma terebrans durch Hirnabzess mit Hirnkompression und Blutungsanamie. Dermatol Monatsschr, 175: 251–255, 1989.
25.
SchroederM., KestlmeierR., SchlegelJ., TrappeA.E.: Extensive cerebral invasion of a basal cell carcinoma of the scalp. Eur J Surg Oncol, 5: 510–511, 2001.
KoppJ., PolykandriotisE., LoosB., SeyhanH., KrickhahnM., KneserU., BachA.D., HorchR.E.: Giant rodent ulcer of the elbow requiring defect coverage by preconditioned latissimus dorsi pedicled myocutaneous flap following excision. J Eur Acad Dermatol Venereol, 21: 252–254, 2007.
35.
UnluR.E., OrbayH., UysalA.C., AlagozM.S., KilincH., SensozO., OrtakT.: Unusual and giant tumors of head and neck region. J Craniofac Surg, 17: 1219–1229, 2006.
36.
Mc MenaminM.E., GohS.G., PobletE., GostelowB.E., RobsonA., CalonjeE.: Sarcomatoid basal cell carcinoma-predilection for osteosarcomatous differentiation: a series of 11 cases. Am J Surg Pathol, 30: 1299–1308, 2006.
SanzH., CalzadoL., Sanchez-LargoE., SeguradoA., Rodriguez-PeraltoJ.L., VanaclochaF.: [Giant ulcer on the back]. Actas Dermosifiliogr, 97: 145–147, 2006.
40.
KeenanR., HopkinsonJ.M.: Pulmonary metastases from a basal cell carcinoma. J Cutan Pathol, 8: 235–240, 1981.
41.
BarnetsonR.S., HallidayG.M.: Regression in skin tumours: a common phenomenon. Australas J Dermatol, 38 Suppl 1: S63–S65, 1997.
42.
BreuningerH., PeschM., DietzK., RassnerG.: [Quantitative analysis of recurrence and spontaneous regression of basalioma parts left in situ] Quantitative Analyse der Rezidivierung bzw. Spontanregression von in situ belassenen Basaliomanteilen. Hautarzt, 43: 561–565, 1992.
