Abstract
An umbilical nodule may be an early or late sign of metastatic spread from an internal malignancy. Usually it appears when the internal malignancy is widely disseminated and has been previously diagnosed. More rarely, such a nodule is the first sign of disease and eventually results in the diagnosis of the primary tumor. We present two cases which document examples of both events, in order to focus on the most relevant aspects of this condition.
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References
1.
Walshe
W.H.
: Nature and treatment of cancer , Vol 92 . Taylor and Walton , London , 1846 .
2.
Storer
H.R.
: Circumscribed tumour of the umbilicus closely simulating umbilical hernia. Boston Med Surg J , 19 : 73 , 1864 .
3.
Galvañ
G.V.
: Sister Mary Joseph's nodule (letter). Ann Int Med , 128 : 410 , 1998 .
4.
Saito
H.
,
Shimokata
K.
,
Yamada
Y.
,
Nomura
F.
,
Yamori
S.
: Umbilical metastasis from small cell carcinoma of the lung. Chest , 101 : 288 –289 , 1992 .
5.
Idelevich
E.
,
Husar
M.
,
Fenig
E.
,
Brenner
B.
,
Ben-Barruch
N.
,
Adi
S.
: Umbilical metastasis as the presenting symptom of non-small-cell lung cancer. J Clin Oncol , 18 : 3187 –3192 , 2000 .
6.
Catterjee
S.N.
,
Bauer
H.M.
: Umbilical metastasis from carcinoma of the pancreas. Arch Dermatol , 116 : 954 –955 , 1980 .
7.
Khan
A.J.
,
Cook
B.
: Metastatic carcinoma of the umbilicus: “Sister Mary Joseph's nodule”. Cutis , 60 : 297 –298 , 1997 .
8.
Sahai
K.
,
Kapila
K.
,
Verma
K.
: Fine-needle aspiration cytology of umbilical nodules: “Sister Joseph's nodule”. Diagn Cy-topathol , 25 : 309 –310 , 2001 .
9.
Barrow
M.
: Metastatic tumors of the umbilicus. J Chronic Dis , 19 : 1113 –1117 , 1966 .
10.
Zeligman
I.
,
Schwilm
A.
: Umbilical metastasis from carcinoma of the colon. Arch Dermatol , 110 : 911 –912 , 1974 .
11.
Brody
H.J.
,
Stallings
W.P.
,
Fine
R.M.
,
Someren
A.
: Carcinoid in an umbilical nodule. Arch Dermatol , 114 : 570 –572 , 1978 .
12.
Zhang
Y.
,
Selvaggi
S.M.
: Metastatic islet cell carcinoma to the umbilicus: diagnosis by fine-needle aspiration. Diagn Cy-topathol , 29 : 91 –94 , 2003 .
13.
Ching
A.S.C.
,
Lai
C.W.
: Sonography of umbilical metastasis (sister Mary Joseph's nodule): from embryology to imaging. Abdom Imaging , 27 : 746 –749 , 2002 .
14.
Amaro
R.
,
Goldestein
J.A.
,
Cely
C.M.
,
Rogers
A.I.
: Pseudo Sister Mary Joseph's nodule. Am J Gastroenterol , 94 : 1949 –1950 , 1999 .
15.
Steck
W.D.
,
Helwig
E.B.
: Tumors of umbilicus. Cancer , 18 : 907 –915 , 1965 .
16.
Majmudar
B.
,
Wiskind
A.K.
,
Croft
B.N.
,
Dudley
A.G.
: The Sister (Mary) Joseph nodule: its significance in gynecology. Gynecol Oncol , 40 : 152 –159 , 1991 .
