Tumors of the small intestine are rare and usually occur in association with genetic disease and chronic intestinal inflammation. We report three cases of small bowel adenocarcinoma in patients affected by celiac disease who received a safe chemotherapy regimen (FOLFOX IV or LV5FU2) after tumor resection.
SagerG.F.: Primary malignant tumors of the small intestine.Am J Surg,135: 601–608, 1978.
2.
CiccarelliO., WelchJ.P., KentG.: Primary malignant tumors of the small bowel: the Hartford Hospital experience 1969-1983.Am J Surg,153: 350–354, 1987.
3.
MartinR.G.: Malignant tumors of the small intestine.Surg Clin North Am,66: 779–784, 1986.
4.
GillS.S., HeumanD.M., MihasA.A.: Small intestinal neoplasm.J Clin Gastroenterol,33: 267–282, 2001.
5.
FarrellR.J., KellyM.: Diagnosis of celiac sprue.Am J Gastroenterol,96: 3237–3246, 2001.
6.
GoughK.R., ReadA.E., NaishJ.M.: Intestinal reticulosis as a complication of idiopathic steatorrhoea.Gut,3: 232–239, 1962.
7.
HarrisO.D., CookeW.T., ThompsonH., WaterhouseJ.A.M.: Malignancy in adult coeliac disease and idiopathic steatorrhoea.Am J Med,2: 899–912, 1967.
8.
HolmesG.K.T., DunnG.I., CockelR., BrookesV.S.: Adenocarcinoma of the upper small bowel complicating coeliac disease.Gut,21: 1010–1016, 1980.
9.
SwinsonC.M., SlavinG., ColesE.C., BoothC.C.: Coeliac disease and malignancy.Lancet,1: 111–115, 1983.
10.
LoganR.F.A., RifkindE.A., TurnerI.D., FergusonA.: Mortality in coeliac disease.Gastroenterology,97: 265–271, 1989.
11.
VoltaU., De FranceschiL., MolinaroN.: Frequency and significance of anti-gliadin and anti-endomysial antibodies in autoimmune hepatittis.Dig Dis Sci,43: 2190–2195, 1998.
12.
JacobsenM.B., FausaO., ElgjoK., SchrumpfE.: Hepatic lesions in adult coeliac disease.Scand J Gastroenterol,25: 656–662, 1990; erratum in 25(10): inside front cover, 1990.
13.
PricoloV.E., MangiA.A., AswadB., BlandK.I.: Gastrointestinal malignancies in patients with celiac sprue.Am J Surg,176: 344–347, 1998.
14.
HolmesG.K., PriorP., LaneM.R., PopeD., AllanR.N.: Malignancy in coeliac disease - effect of a gluten free diet.Gut,30: 333–336, 1989.
15.
WheelerJ.M.D., WarrenB.F., MortensenN.J., KimH.C., BiddolphS.C., EliaG., BeckN.E., WilliamsG.T., ShepherdN.A., BatemanA.C., BodmerW.F.: An insight into the genetic pathway of adenocarcinoma of the small intestine.Gut,50: 218–223, 2002.
16.
BlakerH., von HerbayA., PenzelR., GrossS., OttoH.F.: Genetics of adenocarcinomas of the small intestine: frequent deletions at chromosome 18q and mutations of the SMAD4 gene.Oncogene,21: 158–164, 2002.
