Is There an Advantage for Oral Therapy in Elderly? Uft

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References

Koehne

C.H.

, Grothey

, Bokemeyer

: Chemotherapy in elderly patients with colorectal cancer. Ann Oncol, 12: 435–442, 2001.

Fentiman

I.S.

, Tirelli

, Monfardini

: Cancer in the elderly: why so badly treated? Lancet, 335: 1020–1022, 1990.

Arriagada

, Le Chevalier

, Pignon

J.P.

: Initial chemotherapeutic doses and survival in patients with limited small-cell lung cancer. N Engl J Med, 329: 1848–1852, 1993.

Diasio

R.B.

: Clinical implications of dihydropyrimidine dehydrogenase inhibition. Oncology, 3: 17–21, 1999.

Hoff

P.M.

, Royce

, Medgyesy

: Oral fluoropyrimidines. Semin Oncol, 26: 640–646, 1999.

Pazdur

, Douillard

J.Y.

, Skillings

: Multicenter phase III study of 5fluorouracil (5FU) or UFT in combination with leucovorin (LV) in patients with metastatic colorectal cancer. Proc ASCO, 18: 263a, 1999.

Carmichael

, Popiela

, Radstone

: Randomized comparative study of Orzel (oral UFT plus leucovorin) versus parenteral 5FU plus leucovorin in patients with metastatic colorectal cancer. Proc ASCO, 18: 264a, 1999.

Diaz-Rubio

, Sastre

, Abad

: UFT plus or minus calcium folinate for metastatic colorectal cancer in older patients. Oncology, 13: 35–40, 1999.

Feliu

, Gonzalez Baron

, Espinosa

: Uracil and tegafur modulated with leucovorin. An effective regimen with low toxicity for the treatment of colorectal carcinoma in the elderly. Oncopaz Cooperative Group. Cancer, 79: 1884–1889, 1997.

10.

Feliu

, Calvillo

, Escribano

: Neoadjuvant therapy of rectal carcinoma with UFT-folinic acid plus radiotherapy. Proc ASCO, 19: 266a, 1999.