Cronoterapia

Lévi F. , Misset J.L. , Brienza S. : A chronopharmacologic phase II clinical trial with 5-fluorouracil, folinic acid and oxaliplatin using an ambulatory multichannel programmable pump. High antitumor effectiveness against metastatic colorectal cancer. Cancer 1992; 69: 893–900.

Lévi F. , Perpoint B. , Garufi C. : Oxaliplatin activity against metastatic colorectal cancer. A phase II study of 5-day continuous infusion at circadian rhythm modulated rate. Eur J Cancer 1993; 29A: 1280–4.

Lévi F. , Zidani R. , Vannetzel J.M. : Chronomodulated versus fixed-infusion-rate delivery of ambulatory chemotherapy with oxaliplatin, fluorouracil, and folinic acid in patients with colorectal cancer metastases: a randomized multi-institutional trial. J Natl Cancer Inst 1994; 86: 1608–17.

Garufi C. , Brienza S. , Misset J.L. : Addition of oxaliplatin to chronomodulated 5-fluorouracil and folinic acid for reversal of acquired chemoresistance in patients with advanced colorectal cancer. Proc ASCO 1995; 14: abs 192.

Garufi C. , Brienza S. , Pugliese P. : Overcoming resistance to chronomodulated 5-fluorouracil and folinic acid by the addition of chronomodulated oxaliplatin in advanced colorectal cancer patients. Anticancer Drugs 2000; 11: 495–501.

Bertheault-Cvitkovic F. , Jami A. , Ithzaki M. : Biweekly intensified ambulatory chronomodulated chemotherapy with oxaliplatin, 5-fluorouracil and folinic acid in patients with metastatic colorectal cancer. J Clin Oncol 1996, 14: 2950–8.

Lévi F. , Zidani R. , Brienza S. : A multicenter evaluation of intensified ambulatory chronomodulated chemotherapy with oxaliplatin, fluorouracil and leucovorin as initial treatment of patients with metastatic colorectal cancer. Cancer 1999, 85: 2532–40.

Lévi F. , Zidani R. , Misset J.L. for the International Organization for Cancer Chronotherapy: Randomised multicentre trial of chronotherapy with oxaliplatin, fluorouracil, and folinic acid in metastatic colorectal cancer. Lancet 1997, 350: 681–6.

Garufi C. , Pietrangeli A. , Aschelter A.M. : Electrophysiological evaluation of oxaliplatin neurotoxicity. Electrophysiological evaluation of oxaliplatin neurotoxicity. Proc ASCO1999; 18: abs 938.

Giacchetti S. , Itzhaki M. , Gruia G. : Long-term survival of patients with unresectable colorectal cancer liver metastases following infusional chemotherapy with 5-fluorouracil, leucovorin, oxaliplatin and surgery. Ann Oncol 1999, 10: 663–9.

Giacchetti S. , Perpoint B. , Zidani R. : Phase III multicenter trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer. J Clin Oncol 2000; 18: 136–47.