Treatment of non-insulin-dependent diabetes mellitus patients with nephropathy of the nephrotic type using 40 μg prostaglandin E1 given intravenously twice daily for 4 weeks reduced the urinary protein concentration. Prostaglandin E1 also increased the total serum protein and serum albumin concentrations, and reduced creatinine clearance and plasma renin activity following frusemide loading. Treatment with the prostaglandin did not, however, significantly affect the blood urea nitrogen and the serum creatinine concentration. It is concluded that prostaglandin E1 has overt effects on diabetic nephropathy.
OkadaSSatoKMiyaiY: Influence of prostaglandin E1 on proteinuria in diabetic nephropathy. Clin Trials J1985; 22: 263–266.
2.
ParvingH-HRutiliFGranathK: Effect of metabolic regulation on renal leakiness to dextran molecules in short-term insulin-dependent diabetics. Diabetologia1979; 17: 157–160
3.
StrongCGBohrDF: Effects of prostaglandin E1, E2, A1 and F1α on isolated vascular smooth muscle. Am J Physiol1967; 213: 725–733.
4.
NeumayerH-HWagnerKSchultzeG: Influence of prostaglandins A1, E1, E2, and F2α on renal blood flow and plasma renin activity. Renal Physiol1982; 5: 57–67.
5.
DitzelJJunkerK: Abnormal glomerular filtration rate, renal plasma flow, and renal protein excretion in recent and short-term diabetics. Br Med J1972; ii: 13–19.
6.
MogensenCE: Glomerular filtration rate and plasma flow in long-term juvenile diabetics without proteinuria. Br Med J1972; iv: 257–259.
7.
DitzelJBrochner-MortensenJ: The kidney in diabetes. In: Recent Trends in Diabetes Research (BostrumHLjungstedtN, eds). Stockholm: Almqvist and Wiksell, 1982; p 179.
8.
HommelEMathiesenEArnold-LarsenS: Effects of indomethacin on kidney function in type 1 (insulin-dependent) diabetic patients with nephropathy. Diabetologia1987; 30: 78–81.
9.
ParvingH-HAndersenARSmidtUM: Early agressive antihypertensive treatment reduces rate of decline in kidney function in diabetic nephropathy. Lancet1983; i: 1175–1179.
10.
TagumaYKitamotoYFutakiG: Effect of Captopril on heavy proteinuria in azotemic diabetics. New Eng J Med1985; 313: 1617–1620.
11.
DworkinLDIchikawaIBrennerBM: Hormonal modulation of glomerular function. Am J Physiol1983; 244: F95–F104.
12.
NiwaTMaedaKNaotsukaY: Improvement of renal function with prostaglandin E1 infusion in patients with chronic renal disease. Lancet1982; i: 687.
