Percutaneous Treatment of Acute Soft Tissue Lesions with Naproxen Gel and Ketoprofen Gel

Abstract

A randomized, independent-group, single-blind study was performed to compare the analgesic efficacy and the local and cosmetic tolerability of 3 – 5 cm of 10% naproxen gel with 10% ketoprofen gel in 30 patients complaining of moderate or severe pain due to acute soft tissue lesions. Both drugs were administered topically and were applied to the painful area at least once every 12 h as required. Naproxen gel was effective, cosmetically acceptable and safe in the treatment of acute soft tissue lesions. Efficacy and tolerability of both naproxen gel and ketoprofen gel were comparable, although naproxen gel produced a significantly greater reduction in pain on deep palpation by the third day of treatment.