To demonstrate whether or not fine needle aspiration biopsy caused release of thyroglobulin into the circulation and if there was a correlation between histological diagnosis and thyroglobulin release from thyroid during aspiration, serum thyroglobulin concentrations were determined in 12 patients with solitary cold nodule or multinodular goitre. Of the 12 patients studied, seven had significant (P < 0.05) elevations of serum thyroglobulin after aspiration. It is suggested that circulating thyroglobulin may increase after minor trauma to thyroid tissue such as following fine needle aspiration.
TorrigianiGDoniachDRoittIM: Serum thyreoglobulin in healthy subjects and in patients with thyroid disease. J Clin Endocrinol Metab1969; 29: 305–314.
2.
ShlossbergAHJacobsonJCIbbertsonHK: Serum thyroglobulin in the diagnosis and management of thyroid carcinoma. Clin Endocrinol1979; 10: 17–22.
3.
WalfishPGMiskinMRosenIB: Application of special diagnostic techniques in the management of nodular goitre. Can Med Assoc J1976; 115: 35–40.
4.
LeverEGRefetoffSScherbergNH: The influence of percutaneous fine needle aspiration on serum thyroglobulin. J Clin Endocrinol Metab1982; 56: 26–29.
5.
MillerJM: Needle biopsy of the thyroid. Method and recommendations. Thyroid Today1982; 5: 1–5.
6.
SchneiderABPervosR: Radioimmunoassay of thyroglobulin: effect of antithyroglobulin antibodies. J Clin Endocrinol Metab1978; 47: 126–129.
7.
CataniaACantalamessaLGaspariniP: Circulating thyroglobulin and antithyroglobulin antibodies after fine needle aspiratin of thyroid nodules. Horm Metab Res1985; 17: 49–55.
