Calcium,Phosphorus and Aluminium Concentrations in the Central Nervous System,Liver and Kidney of Rabbits with Experimental Atherosclerosis: Preventive Effects of Vinpocetine on the Deposition of These Elements
Restricted accessResearch articleFirst published online March, 1990
Calcium,Phosphorus and Aluminium Concentrations in the Central Nervous System,Liver and Kidney of Rabbits with Experimental Atherosclerosis: Preventive Effects of Vinpocetine on the Deposition of These Elements
Calcium, phosphorus and aluminium concentrations in the central nervous system, liver and kidneys were determined in 16 rabbits with atherosclerosis experimentally induced by a cholesterol-rich diet and the protective effect of 3 or 10 mg/kgday vinpocetine (14-ethoxycarbonyl-(3α,16α-ethyl)-14,15-eburnamenine) given orally on the deposition of these elements was assessed. Rabbits fed a cholesterol-rich diet developed atherosclerosis after 3 months and these rabbits possessed high concentrations of calcium, phosphorus and aluminium in the central nervous system, determined by neutron activation analysis. In atherosclerotic rabbits fed a vinpocetine supplement, there was a decrease in concentrations of these elements in tissues. It is suggested that calcium, phosphorus and aluminium may be implicated in the aetiology of atherosclerosis and that vinpocetine may have a preventive action on the deposition of these elements in central nervous tissue, liver and kidney.
YasuiM, YanoI, OtaK: Preventive effect of vinpocetine on calcification: atherosclerosis in experimental rabbits. Acta Neurol Scand1989; 79: 239–242.
2.
HagiwaraH, EndoT, HidakaH: Effect of vinpocetine (TCV-3B) on cyclic GMP metabolism. Folia Pharmacol Japon1982; 80: 317–323.
3.
TokiwaT, SenooN, NaritaS: Effect of vinpocetine (TCV-3B) and apovincaminic acid (AVA) on the relaxation of rabbit basilar arteries. Clin Rep(Tokyo)1982; 16: 2179–2192.
4.
NakamuraH, KondoK, HirataF: Changes in lipoprotein lipids and apolipoproteins by the administration of Calan. Ther Res (Tokyo) 1986; 4: 141–144.
5.
KakihanaM, SunoM, ShibotaM: Protective effect of vinpocetine on experimental brain ischemia. Folia Pharmacol Japon1982; 80: 225–229.
6.
BoucekMM, SnydermanR: Calcium influx requirement for human neutrophilic chemotaxis: inhibition by lanthanum chloride. Science1976; 193: 905–907.
7.
HelinP, LorenzenI, GarbarschC: Morphological and biochemical changes in rabbit aorta after a single dilatation injury. Circ Res1971; 29: 542–554.
8.
RossR: The pathogenesis of atherosclerosis – an update. N Engl J Med1986; 314: 488–500.
9.
LochrR, NeysesL: The cholesterol content of the human erythrocyte influences calcium influx through the channel. Biochem Biophys Res Commun1984; 124: 822–828.
10.
AnderssonR: Role of cyclic AMP and Ca++ in mechanical and metabolic events in isometrically contracting vascular smooth muscle cells. Acta Physiol Scand1973; 87: 84–95.
11.
NumanoF, WatanabeY, TakenoK: Microassay of cyclic nucleotides in vessel wall. Exp Mol Pathol1976; 25: 172–181.
12.
HellmanB, SehlinJ, TaljedalIB: Calcium and secretion: distinction between two pools of glucose-sensitive calcium in pancreatic islets. Science1976; 194: 1421–1423.
13.
YuSY, BlumenthalHT: The calcification of elastic fibers. I. Biochemical studies. J Gerontol1963; 18: 119–126.
14.
KramschDM, AspenAJ, ApsteinCS: Suppression of experimental atherosclerosis by the Ca++-antagonist lanthanum. J Clin Invest1980; 65: 967–981.
15.
RosenblumIY, FloraL, EisensteinR: The effect of disodium ethane-1-hydroxy-1, 1-diphosphonate (EHDP) on a rabbit model of atheroarteriosclerosis. Atherosclerosis1975; 22: 411–424.
16.
YasuiM, YanoI, OtaK: Scavenger effect of elastase on calcifications in liver, kidney and central nervous system tissues of rabbits with atherosclerosis induced by cholesterol-rich diet. J Int Med Res1989; 17: 350–357.
17.
GarrutoRM, FukatsuR, YanagiharaR: Imaging of calcium and aluminum in neurofibrillary triangle-bearing neurons in parkinsonism-dementia of Guam. Proc Natl Acad Sci USA1984; 81: 1875–1879.
18.
De BoniU: Cultured cells of the nervous system, including human neurones, in the study of the neurodegenerative disorder, Alzheimer's disease: an overview. Xenobiotica1985; 15: 643–647.
19.
PerlDP, GajdusekDC, GarrutoRM: Intraneuronal aluminum accumulation in amyotrophic lateral sclerosis and parkinsonism-dementia of Guam. Science1982; 217: 1053–1055.
20.
YaseY: Metal studies of ALS – further development. In: Amyotrophic Lateral Sclerosis: Recent Advances in Research and Treatment (TsubakiT, YaseY, eds). Amsterdam: Elsevier, 1988; pp 59–65.
21.
CrapperDR, Van BerkumMFA: Aluminum: a role in degenerative brain disease associated with neurofibrillary degeneration. Prog Brain Res1986; 70: 399–409.
22.
AltmannP, DhaneshaU, HamonC: Distribution of function by aluminium in haemodialysis patients without overt aluminium toxicity. Lancet1989; ii: 7–12.
23.
KritchevskyD, TepperSA, VesselinovitchD: Cholesterol vehicle in experimental atherosclerosis. Part II. Peanut oil. Atherosclerosis1971; 14: 53–64.
MizumotoY, IwataS, SasajimaK: Reactor neutron activation analysis for aluminum in the presence of phosphorus and silicon – contribution of 28A1 activities from 3lP(n,α)28Al and 28Si (n,p) 28A1 reactions. Radioisotopes1984; 33: 8–14.
26.
GabbianiG, TuchweberB, PerraultG: Studies in the mechanism of metal-induced soft tissue calcification. CalcifTiss Res1970; 6: 20–31.
AlcoladoJC, MooreIE, WellerRO: Calcification in the human choroid plexus, meningiomas and pineal gland. Neuropath Appl Neurobiol1986; 12: 235–250.
29.
YoshidaS: X-ray microanalytic studies on ALS. II. The interrelationships of intraspinal blood supply, metal deposition and degenerative changes. Clin Neurol (Tokyo)1979; 19: 283–291.
