Sixty patients were enrolled in a controlled randomized single-blind study to compare the efficacy and tolerability of 200 mg/day nimesulide and 300 mg/day flurbiprofen given for 7 days, in the treatment of non-infectious acute inflammation of the upper respiratory tract. Patients were diagnosed as follows: pharyngitis, 20 (33.4%) cases; laryngitis 11 (18.3%) cases; tonsillitis, eight (13.3%) cases; and mixed forms, 21 (35.0%) cases. Both drugs showed the same efficacy in reducing mucosal congestion, local redness, fever and sore throat. Nimesulide treatment gave rise to fewer and less severe side-effects than flurbiprofen treatment.
VerhulstJ: Le laringiti. In: Manuale di Otorinolaringoiatria (PortmanM, ed.). Milan: Masson, 1985; pp 314–320.
2.
MantovaniMDel PràML: Nuova prospettiva terapeutica nella patologia infiammatoria della vie aeree: AulinOto-Rino-Laring1987; 37: 1–7.
3.
FerrettiMZolloC: La nimesulide nel trattamento delle flogosi in otorinolaringoiatria. Oto-Rino-Laring1987; 37: 363–368.
4.
RestaOFoschino BarbaraMPTetroA: Efficacia e tollerabilità della nimesulide in confronto al fenilprenazone in soggetti affetti da infiammazione delle vie aeree superiori. Oto-Rino-Laring1987; 37: 451–458.
5.
OrlandiOBagnascoGBrossaW: La nimesulide nella patologia infiammatoria delle vie aeree. Gaz Med It Arch Sci Med1987; 146: 3–7.
6.
AllegraL: Nimesulide in broncopneumologia. Attual Ter Int1986; 33: 10–11.
7.
BiscariniLPatoiaLDel FaveroA: Nimesulide–a new non steroidal anti-inflammatory agent. Drugs Today1988; 24: 23–27.
AmbrosiniE: Farmacologia clinica della nimesulide. Attual Ter Int1986; 33: 7.
10.
Emami NouriM: Nimesulide for treatment of acute inflammation of the upper respiratory tract. Clin Ther1984; 6: 142–150.
11.
ReinerM: Nimesulide and antibiotics in the treatment of acute infections of the respiratory tract. Curr Med Res Opin1983; 8: 487–492.
12.
TomassiniPDi NicolaAParisiD: Nuova terapia sintomatica delle affezioni flogistiche delle vie respiratorie. Min Pneum1986; 25: 41–46.
13.
StormeXLebacqE: Activite et tolerance de la nimesulide, un nouvel agent anti-inflammatoire non-steroidien, en pathologie O.R.L. Ars Medici1985; 40: 65–69.
14.
OttavianiA: Nimesulide in otorinolaringoiatria. Attual Ter lnt1986; 33: 8–9.
15.
CasciarriITofanettiOCipollaPV: Effect of the new antiinflammatory drug nimesulide on 6-keto-PGF1ALFA, PGE2 and TBX2 gastric production, compared with ASA and salsalate. In: Proceedings of the 22nd Congress of the Italian Society of Pharmacology.Bologna: Negri,. 1984; No. 218, p 449.
16.
RainsfordKD: The comparative gastric ulcerogenic activities of non-steroidal anti-inflammatory drugs. Agents Actions1977; 7: 573–577.
17.
MilvioCBorelliniPMilvioE: Tolerability of nimesulide. A long-term clinical trial. Arch Med Int1983; 35: 51–60.
18.
CattiA: Nimesulide suspension: dose finding in children with fever due to upper respiratory tract inflammatory disease. In: Proceedings of the 18th International Congress of Pediatrics, 7–12 July 1986, Honolulu, No. 189.
19.
CapsoniFVenegoniEMinonzioF: Inhibition of neutrophil oxidative metabolism by nimesulide. Agents Actions1987; 21: 121–129.
20.
RuferCSchillingerEXBottcherI: Non-steroidal anti-inflammatories–XII. Mode of action of anti-inflammatory methane sulfonanilides. Biochem Pharmacol1982; 31: 3591–3596.
21.
PonciniLBreroPRobustoC: Effetto del flurbiprofen associate ad un antibiotico nelle broncopneumopatie inflammatorie in pediatria. Minerva Pediatr1987; 39: 215–219.
22.
CiferriGBianchini CiampoliMPassaliMG: Il flurbiprofen nella terapia delle flogosi delle alte die respiratorie. Riv ORL Aud Fon1986; 6: 135–138.
