A controlled, parallel group study of the analgesic efficacy of flupirtine maleate, was compared against diclofenac sodium in 40 orthopaedic patients with post-operative pain. Clinically, both drugs were of equal analgesic efficacy. A mathematical model has been developed, however, to evaluate the speed, intensity and duration of the analgesic effect and provides data which significantly favour flupirtine maleate in the treatment of these patients.
JakovlevVSofiaRDAchterrath-TuckermannU: Untersuchungen zur pharmakologischen Wirkung von Flupirtin, einem strukturell newartingen Analgetikum. Arzneimittelforsch1985; 35: 30–31.
2.
NickelBHerzAJakovlevV: Untersuchungen zum Wirkungmechanismus des Analgetikum Flupirtin. Arzneimittelforsch1985; 35: 1402–1403.
3.
JakovlevVAchterrath-TuckermannUVon SchlichtegrollA: Allgemeine pharmakologische Untersuchungen mit dem Analgetikum Flupirtin. Arzneimittelforsch1985; 35: 44–45.
4.
CeccarelliGCiampiniMFrontespeziS: Flupirtine: the first Italian experience. Postgrad Med J1987; 63 (suppl 3): 105–106
5.
Rieth Muller-WinzenH: Flupirtine in the treatment of postoperative pain. Postgrad Med J1987; 63 (suppl 3): 61–63
6.
ScheefW: Analgesic efficacy and safety of oral flupirtine in the treatment of cancer pain. Postgrad Med J1987; 63 (suppl 3): 67–68
7.
McMahonFGArndtWFNewtonJJ: Clinical experience with flupirtine in the U.S. Postgrad Med J1987; 63 (suppl 3): 81–85
8.
BrogdenRN: Diclofenac. A review of the actions and uses. Drugs1980; 20: 24–29.
