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Abstract

The results are presented of a controlled study in male Wistar rats into the effects of 24R,25-dihydroxyvitamin D₃ on blood glucose levels, bone calcium content and ADP-induced platelet aggregation in streptozocin-induced diabetes mellitus. Blood glucose levels were shown to be decreased by 10 μg/kg 24R,25-dihydroxyvitamin D₃. The reduced bone calcium content associated with diabetes mellitus was returned to normal levels with both 1 and 10 μg/kg 24R,25-dihydroxyvitamin D₃. It was also shown to exhibit dose-dependent anti-platelet activity. The data suggest that 24R,25-dihydroxyvitamin D₃ might have potential as a mild therapeutic agent in the treatment of osteoporosis and platelet hyperactivity associated with diabetes mellitus.

Keywords

streptozocin-induced diabetes bone calcium rats

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References

Norman

: 1, 25-Dihydroxyvitamin D₃ and 24,25-dihydroxyvitamin D₃: key components of the vitamin D endocrine system. Contrib Nephrol 1980; 18: 1–11.

Ljunghall

Lithell

Lind

: Assessment of the role of vitamin D in insulin secretion. In: Vitamin D. A Chemical, Biochemical and Clinical Update. 1985; pp 853–857.

Cade

Norman

: Influence of vitamin D status on insulin secretion in vivo and glucose tolerance in the rat. In: Vitamin D. A Chemical, Biochemical and Clinical Update. 1985; pp 861–862.

Kadowaki

Cade

Fujita

: Normal A W time course study of insulin secretion in the isolated, perfused rat pancreas after 1,25-dihydroxyvitamin D₃ administration. In: Vitamin D. A Chemical, Biochemical and Clinical Update. 1985; pp 863–864.

Harmeyer

Lachenmaier-Currle

Kaune

: The role of vitamin D for the glucose stimulated insulin release from the endocrine pancreas. In: Vitamin D. A Chemical, Biochemical and Clinical Update. 1985; pp 865–866.

Albright

Reifenstein

: Parathyroid Glands and Metabolic Bone Disease: Selected Studies. Baltimore: Williams & Wilkins, 1948.

Berney

: Osteoporosis and diabetes mellitus. J Iowa Med Soc 1952; 42: 10–12.

Saggese

Federico

Cesaretti

: Osteoporosis and calcium regulating hormones in insulin-dependent diabetes mellitus (IDDM). In: Vitamin D. A Chemical, Biochemical and Clinical Update. 1985; pp 871–872.

Kingsley

Getchell

: Clin Chem 1960; 6: 466.

10.

Corvol

Dumontier

Garabedian

: Vitamin D and cartilage. II. Biological activity of 25-hydroxycholecalciferol and 24R,25- and 1,25-dihydroxycholecalciferols on cultured growth plate chondrocytes. Endocrinology 1978; 102: 1269–1274.

11.

Endo

Kiyoki

Kawashima

: Vitamin D₃ metabolites and PTH synergistically stimulate bone formation chick embryonic femur in vitro . Nature 1980; 286: 262–264.

12.

Sömjen

Kaye

Binderman

: 24R,25-Dihydroxyvitamin D stimulates creatine kinase BB activity in chick cartilage cells in culture. FEBS Lett 1984; 167: 281–284.

13.

Tsutsumi

Hoshiba

Moriuhi

: Regulatory effect of calcium-regulating hormones on the synthesis and/or secretion of bone-γ-carboxyglutamic acid-containing protein in chick embryonic calvaria in vitro . J Nutr Sci Vitaminol (Tokyo) 1986; 32: 157–169.

14.

Matsumoto

Ezawa

Morita

: Effect of vitamin D metabolites on bone metabolism in a rat model of postmenopausal osteoporosis. J Nutr Sci Vitaminol (Tokyo) 1985; 31(suppl): S61–S65.

15.

Binderman

Sömjen

: 24R,25-Dihydroxycholecalciferol induces the growth of chick cartilage in vitro . Endocrinology 1984; 115: 430–432.

16.

Sömjen

Binderman

Weisman

: The effects of 24R,25-dihydroxycholecalciferol on ornithine decarboxylase activity and on DNA synthesis in the epiphysis and diaphysis of rat bone and in the duodenum. Biochem J 1983; 214: 293–298.

Effect of 24 R,25-Dihydroxyvitamin D 3 in Experimental Diabetic Rats

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