Microangiographic and conventional histopathologic investigations of the kidney were compared in 15 alloxan diabetic and 7 nondiabetic control rats. Contrary to the relatively sparse histologic lesions, microangiography disclosed advanced vascular abnormalities, including arteriolar aneurysms, which increased with the duration of diabetes. It is concluded that microangiography is a sensitive and suitable method for studying the development of microvascular lesions of the kidney in experimental diabetes.
BellmanS.: Microangiography. Acta Radiol. Suppl.102 (1953), p. 1.
2.
ChapmanM.AshkenM. H.: Some uses of microangiography in a study of the renal vasculature. Clin. Radiol.20 (1969), 301.
3.
GriffithsG. J.KormanoM.MorrisT.: Relationship of perfusion pressure to the microcirculation of the preserved canine kidney. Invest. Radiol.12 (1977), 338.
4.
HäggE.: Renal lesions in rats with long-term alloxan diabetes. A semiquantitative light microscopic study with particular reference to the glomeruli. Acta Pathol. Microbiol. Immunol. Scand. A82 (1974), 199.
5.
HillmanB. J.LeeS. M.WilsonG.: In vivo barium microangiography in the mouse. Invest. Radiol.15 (1980), 145.
6.
ImaizumiM.NukadaT.TadaK.AbeH.: A microangiographic and histologic study of the kidney in Kimmelstiel-Wilson disease. Med. J. Osaka Univ.25 (1974), 23.
7.
KorecR.: Experimental diabetes mellitus in rat. Publishing House of the Slovak Academy of Sciences, Bratislava 1967.
8.
KormanoM.: Technical aspects in microangiography using barium sulfate (Micropaque) suspension. Invest. Radiol.2 (1967), 14.
9.
LeemingB. W. A.SpokesK. C.SilvaP.: Effect of meglumine iothalamate on renal hemodynamics and function in the diabetic rat. Invest. Radiol.20 (1985), 971.
10.
LjungquistA.: The intrarenal arterial pattern in the normal and diseased human kidney. A microangiographic and histologic study. Acta Med. Scand. Suppl.410 (1963), p. 1.
11.
MoffatD. B.FourmanJ.: The vascular pattern of the rat kidney. J. Anat.97 (1963), 543.
12.
NakamotoY.TakazakuraE.HayakawaH.: Intrarenal microaneurysms in diabetic nephropathy. Lab. Invest.42 (1980), 433.
13.
RubinP.: Microangiography. Facts and artifacts. Radiol. Clin. North Am.2 (1964), 499.
14.
ShyhT.-P.FriedmanE. A.: Uninephrectomy does not potentiate contrast media nephrotoxicity in the streptozotocin-induced diabetic rat. Nephron55 (1990), 170.
