Restricted accessResearch articleFirst published online 1987-5
Comparison of the Accumulation Kinetics of L-(Methyl- 11 C)-Methionine and D-(Methyl- 11 C)-Methionine in Brain Tumors Studied with Positron Emission Tomography
Five patients with glioma were examined with positron emission tomography after the administration of 11C-L-methionine and at a following day with 11C-D-methionine. The rates of accumulation of the tracers were determined in the tumor and in the normal brain tissue according to a graphical technique of Patlak et coll. (24). The accumulation rates for L-methionine were on the average 2.4 times higher than those of D-methionine in the tumors. The corresponding ratio for normal brain tissue was 2.3. It is concluded that in this group of tumors without obvious blood-tumor-barrier breakdown, a stereospecific process with similar properties as in the normal brain tissue, is responsible for the accumulation of the labelled methionine.
BeaneyR. P.: Positron emission tomography in the study of human tumors. Sem. Nucl. Med.14 (1984), 424.
2.
BerglundL.HalldinC., Liua A. and coll.: C-11-methionine kinetics in pregnant rhesus monkeys studied by positron emission tomography. A new approach to feto-maternal metabolism. Acta Obstet. Gynecol. Scand.63 (1984), 641.
3.
BergströmM.: Performance evaluation and improvements of quantitation accuracy in transmission and positron emission computer assisted tomography. Thesis, University of Stockholm, 1982.
4.
BergströmM.BoëthiusJ., Eriksson L. and coll.: Head fixation device for reproducible position alignment in transmission CT and positron emission tomography. J. Comput. Assist. Tomogr.5 (1981), 136.
5.
BergströmM.CollinsV. P., Ehrin E. and coll.: Discrepancies in brain tumor extent as shown by CT and positron emission tomography using Ga-68-EDTA, C-11-glucose and C-11-methionine. J. Comput. Assist. Tomogr.7 (1983), 1062.
6.
BergströmM.LittonJ., Eriksson L. and coll.: Determination of object contour from projections for attenuation correction in cranial positron emission tomography. J. Comput. Assist. Tomogr.6 (1982), 365.
7.
BergströmM.MosskinM., Ericson K. and coll.: Accumulation kinetics of C-11-glucose, (methyl-C-11)-L-methionine and Ga-68-EDTA in brain tumors measured with positron emission tomography. Submitted for publication.
8.
BustanyP.HenryJ. F., Cabanis E. and coll.: Incorporation of L-11-C-methionine in brain proteins studied by P.E.T. in dementia. In: World congress of nuclear medicine and biology, III, Paris. Nuclear medicine and biology advances, p. 2216. Edited by RaynaudC., Pergamon Press, Oxford1983.
9.
BustanyP., de Rotrou J. and coll.: Correlations between clinical state and positron emission tomography measurements of local brain protein synthesis in Alzheimer's dementia, Parkinson's disease and gliomas. In: The metabolism of the human brain studied with positron emission tomography, p. 241. Edited by GreitzT.IngvarD. H.WidenL., Raven Press, New York1985.
10.
EricsonK.LiuaA., Bergström M. and coll.: Positron emission tomography with (methyl-11-C)-L-methionine, 11-C-glucose and 68-Ga-EDTA in the examination of supratentorial tumors. J. Comput. Assist. Tomogr.9 (1985), 683.
11.
GjeddeA.: High- and low-affinity transport of D-glucose from blood to brain. J. Neurochem.36 (1981), 1463.
12.
HubnerK. F.PurvisJ. T., Mahaley S. M. and coll.: Brain tumor imaging by positron emission computed tomography using C-11-labelled amino acids. J. Comput. Assist. Tomogr.6 (1982), 544.
13.
JohnströmP.EhrinE.Stone-ElanderS.NilssonL.: Synthesis of C-11-labelled D- and L-methionine for positron emission tomography. Investigation of the enantiomeric purity of the products. Acta Pharm. Suec.21 (1984), 189.
14.
KonnoR.YasumuraY.: Involvement of D-amino-acid oxidase in D-amino acid utilization in the mouse. J. Nutr.144 (1984), 1617.
15.
LångströmB.HalldinC., Antoni G. and coll.: Synthesis of L- and D-(methyl-C-11)-methionine. To be published in J. Nucl. Med.
16.
LiljaA.BergströmK., Hartvig P. and coll.: Dynamic study of supratentorial gliomas with L-methyl-11-C-methionine and positron emission tomography (PET). Amer. J. Neuroradiol.6 (1985), 505.
17.
LittonJ. E.BergströmM., Eriksson L. and coll.: Performance study of the PC-384 positron camera system for emission tomography of the brain. J. Comput. Assist. Tomogr.8 (1983), 74.
18.
LundqvistH.: Unpublished data.
19.
LundqvistH.StålnackeC. G.LångströmB.JonesB.: Labelled metabolites in plasma after i.v. administration of 11-C-methyl-L-methionine. In: The metabolism of the human brain studied by positron emission tomography, p. 233. Edited by GreitzT.IngvarD. H.WidenL., Raven Press, New York1985.
20.
NeimsA. H.ZieverinkW. D.SmilackJ. D.: Distribution of D-amino acid oxidase in bovine and human nervous tissues. J. Neurochem.13 (1966), 163.
21.
OldendorfW. H.: Brain uptake of radiolabeled amino acids, amines and hexoses after arterial injection. Amer. J. Physiol.221 (1971), 1629.
22.
OldendorfW. H.: Stereospecificity of blood-brain barrier permeability to amino acids. Amer. J. Physiol.224 (1973), 967.
23.
PardridgeW. M.OldendorfW. H.: Transport of metabolic substrates through the blood-brain barrier. J. Neurochem.28 (1977), 5.
24.
PatlakC. S.BlasbergR. G.FenstermacherJ. D.: Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J. Cerebr. Blood Flow Metabol.3 (1983), 1.
25.
PhelpsM. E.BarrioJ. R., Huang S. C. and coll.: The measurement of local cerebral protein synthesis in man with positron computed tomography (PCT) and C-11 L-leucine. (Abstract.)J. Nucl. Med.23 (1982), 6.
26.
RonquistG.ÅgrenG.PonténJ.WestermarkB.: α-amino-isobutyne acid transport into human glia and glioma cells in culture. J. Cell. Physiol.89 (1976), 433.
27.
SchoberO.MeyerG.-J.StolkeD.HundeshagenH.: Brain tumor imaging using C-11-labelled L-methionine and D-methionine. J. Nucl. Med.26 (1985), 98.
