Abstract
Background
Malignant extrahepatic biliary obstruction is most commonly caused by pancreatic cancer or cholangiocarcinoma and is frequently diagnosed at an advanced stage. Palliation with percutaneous metallic stent placement is often required, but data on large-scale outcomes remain limited.
Purpose
To investigate the technical and clinical outcomes of percutaneous metallic stent placement in patients with malignant extrahepatic biliary obstruction and to examine the factors that influence patient survival and stent patency duration.
Material and Methods
Between January 2007 and December 2020, 612 patients (370 men, 242 women, mean age = 63.6 years; age range = 25–90 years) with malignant extrahepatic biliary obstruction were included in this retrospective study.
Results
Percutaneous metallic stents were successfully placed in all 612 patients. A total of 76 (12%) patients had major (n = 50, 8%) or minor (n = 26, 4%) complications. The percutaneous drainage catheter was successfully removed in 553 (90%) patients. In total, 53 patients were lost to follow-up and seven patients underwent subsequent biliary operation after stent placement. Stent occlusion occurred in 158/493 (32%) patients and median stent patency time was 274 days. Multivariate Cox regression analyses revealed that primary malignancy (P <0.001), stent patency (P <0.001), chemotherapy (P <0.001), and isolated biliary obstruction (P = 0.001) were independently associated with longer survival.
Conclusion
Percutaneous metallic stent placement is safe and effective in patients with malignant extrahepatic biliary obstruction. In addition, primary malignancy, stent patency, chemotherapy, and isolated biliary obstruction are significantly associated with longer survival within this poor-prognosis cohort.
Keywords
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