Different hemodynamics of basal ganglia between moyamoya and non-moyamoya diseases using intravoxel incoherent motion imaging and single-photon emission computed tomography

Abstract

Background

Moyamoya disease (MMD) and non-MMD have different pathogenesis, clinical presentation, and treatment policy.

Purpose

To identify differences in hemodynamics between MMD and non-MMD using intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) and single-photon emission computed tomography (SPECT).

Material and Methods

Patients who had undergone ^99mTc-ECD or ¹²³I-IMP SPECT, and IVIM imaging were retrospectively studied. IVIM imaging was acquired using six different b-values. Cerebral blood flow ratio (CBF_R) in the basal ganglia was calculated using a standardized volume-of-interest template. The cerebellum was used as a reference region. IVIM perfusion fraction (f) was obtained using a two-step fitting algorithm. Elliptical regions of interest were placed in bilateral basal ganglia on the IVIM f map. Patients were classified into MMD and non-MMD groups. The correlation between CBF_R and mean IVIM f (f_mean) in the basal ganglia was evaluated using Spearman's rank correlation coefficient.

Results

In total, 20 patients with MMD and 28 non-MMD patients were analyzed. No significant differences in f_mean were observed among MMD, affected hemisphere with non-MMD (non-MMD_aff), and unaffected hemispheres with non-MMD (non-MMD_unaff). A negative correlation was seen between f_mean and CBF_R in the MMD group (r = –0.40, P = 0.0108), but not in the non-MMD group (non-MMD_aff, r = 0.07, P = 0.69; non-MMD_unaff, r = –0.22, P = 0.29). No significant differences were found among MMD and non-MMD patients, irrespective of SPECT tracers.

Conclusion

The combination of IVIM MRI and SPECT appears to allow non-invasive identification of differences in hemodynamics between MMD and non-MMD.