Retinal vein occlusion (RVO) is among the commonest retinal vascular conditions that can cause severe visual loss. However, the relationship between RVO and altered spontaneous brain activity is still unknown.
Purpose
To apply regional homogeneity (ReHo) for the evaluation of abnormal brain activity in patients with RVO and explore the relationship between anomalous cerebral activity and behavioral manifestations.
Material and Methods
Resting-state functional magnetic resonance imaging (rs-fMRI) was performed in 26 patients with RVO (12 men, 14 women) and 24 healthy controls (12 men, 12 women) matched by age, sex, and education. ReHo was used to evaluate the local characteristics of spontaneous brain activity. The receiver operating characteristic (ROC) curve was applied to classify RVO and healthy control characteristics. Pearson correlation analysis was used to assess the relationship between the ReHo value of specific brain regions and clinical manifestations in RVO patients.
Results
ReHo values of the right posterior lobe of the cerebellum, fusiform gyrus, and right inferior temporal gyrus of patients with RVO were remarkably higher than those of controls (P < 0.05). ReHo values of the right cuneus in patients with RVO were significantly lower than those of controls (P < 0.05). ROC curve analysis of each brain region revealed a perfect accuracy of the areas under the curve (AUC). There was a negative correlation between the ReHo values of some regions and clinical manifestations.
Conclusion
RVO may cause dysfunction in many brain regions, which may help reveal the neural mechanisms underlying RVO.
YauJWLeePWongTY, et al.
Retinal veinocclusion: an approach to diagnosis, systemic risk factors and management.Intern Med J2008;
38:904–910.
2.
Thapa R, Paudyal G, Bernstein PS. Demographic characteristics, patterns and risk factors for retinal vein occlusion in Nepal: a hospital-based case-control study. Clinical & Experimental Ophthalmology 2010;38:583–590.
3.
KidaT.Mystery of retinal vein occlusion: vasoactivity of the vein and possible involvement of endothelin-1.Biomed Res Int2017;
2017:4816527.
4.
RogersSMcIntoshRLCheungN, et al.
The prevalence of retinal vein occlusion: pooled data from population studies from the United States, Europe, Asia and Australia.Ophthalmology2010;
117:313–319.
5.
FrangiehGTGreenWRBarraquer-SomersE, et al.
Histopathologic study ofnine branch retinal vein occlusions.Arch Ophthalmol1982;
100:1132–1135.
6.
RimTHKimDWHanJS, et al.
Retinal vein occlusion and the risk of stroke development: a 9-year nationwide population-based study.Ophthalmology2015;
122:1187–1194.
7.
TononiGMcIntoshARRussellDP, et al.
Functional clustering: identifying strongly interactive brain regions in neuroimaging data.Neuroimage1998;
7:133–149.
8.
ZengXJCaiFQZhongYL, et al.
Altered intrinsic regional spontaneous brain activity in patients with optic neuritis: a resting-state functional magnetic resonance imaging study. Neuropsychiatr Dis Treat2015;
11:3065–3073.
9.
HuangXLiSHZhouFQ, et al.
Altered intrinsic regional brain spontaneous activity in patients with comitant strabismus: a resting-state functional MRI study. Neuropsychiatr Dis Treat2016;
12:1303–1308.
10.
HuangXLiDLiHJ, et al.
Abnormal regional spontaneous neural activity in visual pathway in retinal detachment patients: a resting-state functional MRI study.Neuropsychiatr Dis Treat2017;
13:2849–2854.
11.
YanCGZangYF.DPARSF: A MATLAB toolbox for “pipeline” data analysis of resting-state fMRI. Front Syst Neurosci2010;4:13.
12.
FreedmanDJRiesenhuberMPoggioT, et al.
Experience dependent sharpening of visual shape selectivity in inferior temporal cortex.Cereb Cortex2006;
16:1631–1644.
13.
SigalaN.Visual categorization and the inferior temporal cortex.Behav Brain Res2004;
149:1–7.
14.
KravitzDJSaleemKSBakerCI.A new neural framework for visuospatial processing.Nat Rev Neurosci2011;
12:217–230.
15.
YuanXHanYWeiY, et al.
Regional homogeneity changes in amnestic mild cognitive impairment patients.Neurosci Lett2016;
629:1–8.
16.
Grill-SpectorKKnoufNKanwisherN.The fusiform face area subserves face perception, not generic within-category identification.Nat Neurosci2004;
7:555–562.
17.
HashimotoNToyomakiAHiraiM, et al.
Absent activation in medial prefrontal cortex and temporoparietal junction but not superior temporal sulcus during the perception of biological motion in schizophrenia: a functional MRI study. Neuropsychiatr Dis Treat2014;
10:2221–2230.
18.
ChengYMeltzoffANDecetyJ.Motivation modulates the activity of the human mirror-neuron system.Cereb Cortex2007;
17:1979–1986.
19.
AcksonPLMeltzoffANDecetyJ.Neural circuits involved in imitation and perspective-taking.Neuroimage2006;
31:429–439.
20.
JeannerodM.Visual and action cues contribute to the self other distinction.Nat Neuroscin2004;
7:422–423.
21.
DaiHMorelliJNAiF, et al.
Resting-state functional MRI: functional connectivity analysis of the visual cortex in primary open-angle glaucoma patients.Hum Brain Mapp2013;
34:2455–2463.
22.
PaulinMG.The role of the cerebellum in motor control and perception.Brain Behav Evol1993;
41:39–50.
23.
WadaNFunabikiKNakanishiS.Role of granule-cell transmission in memory trace of cerebellum-dependent optokinetic motor learning.Proc Natl Acad Sci USA2014;
111:5373–5378.
24.
KheradmandAZeeDS.Cerebellum and ocular motor control.Front Neurol2011;
2:53.
25.
KoziolLFBuddingDAndreasenN, et al.
Consensus paper: the cerebellum’s role in movement and cognition.Cerebellum2014;
13:151–177.
26.
OverwalleFVPeterM.Functional connectivity between the cerebrum and cerebellum in social cognition: a multi-study analysis. Neuroimage2016;
124:248–255.
27.
LvHLiuZYanF, et al.
Disrupted neural activity in unilateral vascular pulsatile tinnitus patients in the early stage of disease: evidence from resting-state fMRI.Prog Neuropsychopharmacol Biol Psychiatry2015;
3:59.
28.
TuXWangJLiuX, et al.
Aberrant regional brain activities in alcohol dependence: a functional magnetic resonance imaging study.Neuropsychiatr Dis Treat2018;
14:827.
29.
Zhuang L, Liu X, Xu X, et al. Association of the interleukin 1 beta gene and brain spontaneous activity in amnestic mild cognitive impairment. Journal of Neuroinflammation 2012;9:263–263.
30.
ZhangSSWuWLiuZP, et al.
Altered regional homogeneity in experimentally induced low back pain: a resting-state fMRI study.J Neuroeng Rehabil2014;
11:115.
31.
TangYLiuWChenJ, et al.
Altered spontaneous activity in antisocial personality disorder revealed by regional homogeneity.Neuroreport2013;
24:590–595.
32.
GuoWBSunXLLiuL, et al.
Disrupted regional homogeneity in treatment-resistant depression: a resting-state fMRI study.Prog Neuropsychopharmacol Biol Psychiatry2011;
35:1297–1302.
33.
MaFZhangY PMiaoRJ, et al.
Risk factors for dementia with type 2 diabetes mellitus among elderly people in China.Age Ageing2013;
42:398–400.
34.
XiaWQChenYCMaJH.Resting-state brain anomalies in type 2 diabetes: a meta-analysis.Front Aging Neurosci2017;
9:14.
35.
PengJQuHLuoTY, et al.
Abnormal spontaneous brain activity in type 2 diabetes with and without microangiopathy revealed by regional homogeneity.Eur J Radiol2016;
85:607–615.
36.
WangCXFuKLLiuHJ, et al.
Spontaneous brain activity in type 2 diabetics revealed by amplitude of low-frequency fluctuations and its association with diabetic vascular disease: a resting-state fMRI study.PLoS One2014;
9:e108883.
37.
LiCCaiPShiL, et al.
Voxel-based morphometry of the visual-related cortex in primary open angle glaucoma.Curr Eye Res2012;
37:794–802.
38.
LevyIHassonUAvidanG, et al.
Center-periphery organization of human object areas.Nat Neurosci2001;
4:533–539.
39.
KarlJMWhishawIQ.Different evolutionary origins for the reach and the grasp: an explanation for dual visuomotor channels in primate parietofrontal cortex. Front Neurol2013;
4:208.
40.
DixonP.Computation in the dorsal and ventral stream.Cogn Neurosci2010;
1:63–64.
41.
HuangXYeCLZhongYL, et al.
Altered regional homogeneity in patients with late monocular blindness: a resting-state functional MRI study.Neuroreport2017;
28:1085.
42.
HuangXLiHJYeL, et al.
Altered regional homogeneity in patients with unilateral acute open-globe injury: a resting-state functional MRI study.Neuropsychiatr Dis Treat2016;
12:1901–1906.
43.
QianHWangXWangZ, et al.
Altered vision-related resting-state activity in pituitary adenoma patients with visual damage.PLoS One2016;
11:e0160119.
44.
HuangYZhouY.Research on spontaneous activity in adult anisometropic amblyopia with regional homogeneity.IOP Conf Ser:Mater Sci Eng2017;
207:012008.
45.
LinXDingKLiuY, et al.
Altered spontaneous activity in anisometropic amblyopia subjects: revealed by resting-state fMRI.PLoS One2012;
7:e43373.
