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Abstract

Background

The degree of intravascular enhancement influences the diagnosis of plaque in coronary computed tomography angiography (CTA).

Purpose

To evaluate whether the protocol tailored to body surface area (BSA) achieving identical enhancement in different habitus patients receiving different concentration contrast agents (CA) in coronary CTA.

Material and Methods

Patients undergoing coronary CTA randomly received a different concentration of CA with a protocol adapted to BSA. Attenuation and standard deviation were measured at ascending aorta (AAo), left anterior descending coronary artery (LAD), right coronary artery (RCA), paraspinal muscle and peri-coronary adipose tissue. Attenuation and Contrast-to-Noise-Ratio (CNR) were compared among CA groups and BMI-subgroups. Data were compared using ANOVA one-way test, paired Student t test, chi-square test and Kappa test.

Results

In different CA concentration groups, there were no significant differences in attenuation of AAo (477.72, 486.98, 474.50 HU, P = 0.29), LAD proximal (478.47, 487.50, 476.21 HU, P = 0.25) and distal portion (448.81, 451.94, 443.83 HU, P = 0.28), RCA proximal (463.11, 465.60, 479.66 HU, P = 0.09) and distal portion (438.90, 441.36, 448.49 HU, P = 0.27). The enhancement of coronary distal portion were lower than proximal portion (all P < 0.01). No significant differences in CNR of LAD (43.24, 47.37, 44.47, P = 0.12) and RCA (51.74, 50.86, 51.86, P = 0.77) were found among CA groups. There were no significant differences in vascular enhancement among BMI-subgroups (all P > 0.05). Overall subjective image quality and agreement were good.

Conclusion

With the CA injection protocol tailored to BSA, it is feasible to obtain consistent contrast enhancement and image quality in coronary CTA, regardless of CA concentration and patient habitus.

Keywords

Cardiac CT-angiography contrast agents-intravenous body surface area contrast enhancement image quality

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Individualized contrast agents injection protocol tailored to body surface area in coronary computed tomography angiography

Abstract

Background

Purpose

Material and Methods

Results

Conclusion

Keywords

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References