We studied the effect of single doses of the 5-HT1A agonist buspirone (10 mg and 20 mg) on food intake during the menstrual cycle of nine healthy women, none of whom were on a contraceptive pill. In a double-blind placebo-controlled trial, subjects were tested over three cycles, receiving one treatment per cycle. Within each cycle, they were tested at two time points; mid-follicular and late luteal. Food intake following 20 mg buspirone was significantly higher in the luteal phase, suggesting the possibility of pre-menstrually enhanced 5-HT receptor sensitivity.
Anantharaman-Barr H.G., Clavien H., Gmunder B., Pollet P.E. (1988) Nutrient intake and the menstrual cycle. Abstract, 1st European Congress on Obesity, Stockholm, June 1988,143
2.
Anderson I.M. (1989) Serotonin receptors, buspirone and premenstrual syndrome. Lancetiii: 615
3.
Anderson I.M., Cowen P.J. (1992) Effect of pindolol on endocrine and temperature responses to buspirone in healthy volunteers. Psychopharmacology106: 428-432
4.
Bancroft J., Cook A., Davidson D., Bennie J., Goodwin G. (1991) Blunting of neuroendocrine responses to infusion of L-tryptophan in women with perimenstrual mood change. Psychol Med21: 305-312
5.
Bendotti C., Samanin R. (1986) 8-Hydroxy-2(di-n-propylamino) tetralin (8-OH-DPAT) elicits eating in free-feeding rats by acting on central serotonin neurones . Eur J Pharmacol121:147-150
6.
Bond A.J., Lader M.H. (1981) Comparative effects of diazepam and buspirone on subjective feelings, psychological tests and the EEG. Int Pharmacopsychiatr16: 212-220
7.
Both-Orthman B., Rubinow D.R., Hoban C., Malley J., Grover G.N. (1988) Menstrual cycle phase-related changes in appetite in patients with premenstrual syndrome and in control subjects. Am J Psychiatr145: 628-631
8.
Corney R.H., Stanton R. (1991) A survey of premenstrual syndrome. Psychosom Med35: 471-482
9.
Czaja J.A. (1978) Ovarian influences on primate food intake: assessment of progesterone actions. Physiol Behav21: 923-928
10.
Dinan T.G., Barry S., Yatham L.N., Mobayed M., O'Hanlon M. (1990) The reproducibility of the prolactin response to buspirone: relationship to the menstrual cycle. Int Clin Psychopharmacol5: 119-123
11.
Dourish C.T., Hutson P.H., Curzon G. (1986) Para-chloro-phenylalanine prevents feeding induced by the serotonin agonist 8-hydroxy-2(di-n-propylamino)tetralin(8-OH-DPAT) . Psychopharmacology89: 467-471
12.
Dourish C.T., Hutson P.H., Kennett G.A., Curzon G. (1986) 8-OH-DPAT-induced hyperphagia: its neural basis and possible therapeutic relevance. Appetite7 (Suppl): 127-140
13.
Elder M. (1988) Reproduction, obstetrics and gynaecology. Heinemann Professional Publications Ltd, Oxford
14.
Fong A.K., Kretsch M.J. (1993) Changes in dietary intake, urinary nitrogen, and urinary volume across the menstrual cycle. Am J Clin Nutr57:43-46
15.
Gammans R.E., Mayol R.F., Labudde J.A. (1986) Metabolism and disposition of buspirone. Am J Med80 (Suppl 3B): 41-51
16.
Garner D.M., Garfinkel P.E. (1979) The eating attitudes test: an index of the symptoms of anorexia nervosa. Psychol Med9: 273-279
17.
Gilbert F., Dourish C.T. (1987) Effects of the novel anxiolytics gepirone, buspirone and ipsapirone on free feeding and feeding induced 8-OH-DPAT. Psychopharmacology93: 349-352
18.
Gilbert F., Dourish C.T., Brazell S., McClue S., Stahl S.M. (1988) Relationship of increased food intake and plasma ACTH levels to 5-HT1A receptor activation in rats. Psychoneuroendocrinology13: 471-478
19.
Gong E.J., Garrel D., Calloway D.H. (1989) Menstrual cycle and voluntary food intake. Am J Clin Nutr45: 252-258
20.
Goodall E., Silverstone T. (1988) Differential effect of D-fenfluramine and metergoline on food intake in human subjects. Appetite11: 215-228
21.
Goodall E., Trenchard E., Silverstone T. (1987) Receptor blocking drugs and amphetamine anorexia in human subjects. Psychopharmacology92: 484-490
22.
Goodall E., Feeney S., McGuirk J., Silverstone T. (1992) A comparison of the effects of D- and L-fenfluramine and D-amphetamine on energy and macronutrient intake in human subjects. Psychopharmacology106: 221-227
23.
Goodall E.M., Cowen P.J., Franklin M., Silverstone T. (1993) Ritanserin attenuates anorectic, endocrine and thermic responses to D-fenfluramine in human volunteers. Psychopharmacology112: 461-466
24.
Henderson M., Freeman C P L (1987) A self-rating scale for bulimia, the 'BITE'Br J Psychiatr150:18-24
25.
Hill A.J., Blundell J.E. (1989) Food selection, body weight and the premenstrual syndrome (PMS): effect of D-fenfluramine. Appetite12: 215
26.
Hrboticky N., Leiter L.A., Anderson G.H. (1989) Menstrual cycle effects on the metabolism of tryptophan loads. Am J Clin Nutr50: 46-52
27.
Laessle R.G., Tuschl R.J., Schweiger U., Pirke K.M. (1990) Mood changes and physical complaints during the normal menstrual cycle in healthy young women. Psychoneuroendocrinology15: 131-138
28.
Leiter L.A., Hrboticky N., Anderson G.H. (1987) Effects of L-tryptophan on food intake and selection in lean men and women. Ann N Y Acad Sci499: 327-328
29.
Lissner L., Stevens J., Levitsky D.A., Rasmussen K.M., Strupp B.J. (1988) Variation in energy intake during the menstrual cycle: implications for food-intake research. Am J Clin Nutr48: 956-962
30.
Lyons P.M., Truswell A.S., Mira M., Vizzard J., Abraham S.F. (1989) Reduction of food intake in the ovulatory phase of the menstrual cycle. Am J Clin Nutr49:1164-1168
31.
Meltzer H.Y., Flemming R., Robertson A. (1983) The effect of buspirone on prolactin and growth hormone secretion in man. Arch Gen Psychiatr40:1099-1102
32.
O'Keane V., O'Hanlon M., Webb M., Dinan T. (1991) D-Fenfluramine/ prolactin response throughout the menstrual cycle: evidence for an oestrogen-induced alteration. Clin Endocrinol34: 289-292
33.
Peters J.R., Elliott J.M., Grahame-Smith D.G. (1980) The effect of oral contraceptives on platelet noradrenaline and 5-hydroxytryptamine receptors and aggregation. In Turner P (ed.), Clinical pharmacology and therapeutics. Proceedings of plenary lectures symposia and therapeutic sessions of the First World Conference on Clinical Pharmacology and Therapeutics. Macmillan, London, pp.165-174
34.
Rickels K., Freeman E., Sondheimer S. (1989) Buspirone in the treatment of premenstrual syndrome . Lanceti: 777
35.
Rosenblatt H., Dyrenfurth I., Ferin M., Vande Wiele R.L. (1980) Food intake and the menstrual cycle in rhesus monkeys . Physiol Behav24:447-449
36.
Sanders D.J., Warner P., Backstrom T., Bancroft J. (1983) Mood, sexuality, hormones and the menstrual cycle. 1, Changes in mood and physical state: description of subjects and methods . Psychosom Med45: 487-501
37.
Silverstone T., Fincham J., Wells B., Kyriakides M. (1980) The effect of the dopamine receptor blocking drug pimozide on the stimulant and anorectic actions of dextroamphetamine in man . Neuropharmacology19: 1235-1237
38.
Tam W Y K, Chan M-Y., Lee P H K (1985) The menstrual cycle and platelet 5-HT uptake. Psychosom Med47: 352-362
39.
Tarasuk V., Beaton G.H. (1991) Menstrual-cycle patterns in energy and macronutrient intake. Am J Clin Nutr53: 442-447
40.
Wathen N.C., Perry L., Lilford R.J., Chard T. (1984) Interpretation of single progesterone measurement in diagnosis of anovulation and defective luteal phase: observations on analysis of the normal range. Br Med J288: 7-9
41.
Wurtman J.J., Brzezinski A., Wurtman R.J., Laferrere B. (1989) Effect of nutrient intake on premenstrual depression . Am J Obstet Gynecol161:1228-1234
