We investigated the threshold of the platelet release reaction during the luteal phase of the cycle in 46 patients suffering from menstrual migraine (MM) and 27 healthy normal women. The distribution in both groups of the three types of aggregometric curves (types 1, 2 or 3) obtained in response to ADP 1 μM as aggregating agent was evaluated. Among MM sufferers, 19 (41%) showed a type 1 curve, while 14 (31%) had a type 2 curve and 13 (28%) showed an irreversible aggregation with a type 3 pattern. Curve distribution in controls was 18 (67%) for type 1, 8 (30%) for type 2 and 1 (3%) for type 3. A significantly
HaningtonE, JonesRJ, AmcssIAL, WachowiczB.Migraine: a platelet disorder. Lancet1981; 2: 720–3
2.
SteinerTJ, JosephR, Clifford RoseF.Migraine is not a platelet disorder. Headache1985; 25: 434–40
3.
RedmondDE, MurphyDL, BauluJ, ZieglerMG, LakeCR.Menstrual cycle and ovarian hormone effects on plasma and platelet monoamine oxidase (MAO) and plasma dopamine-beta-hydroxylase (DBH) activities in the rhesus monkey. Psychosom Med1975; 37: 417–28
4.
OrchardMA, BottingJH.The influence of sex hormones on rat platelet sensitivity to adenosine-diphosphate. Thromb Haemost1981; 46: 496–9
5.
BenedettoC, MassobrioM, ZoncaM, MelziE, NatteroG, AllaisG, TorreE.Menstrual migraine: a possible pathogenic implication of platelet function. Gynecol Endocrinol1987; 1: 345–53
6.
NatteroG, AllaisG, De LorenzoC, TorreE, AnconaM, BenedettoC, MassobrioM.Menstrual migraine: new biochemical and psychological aspects. Headache1988; 28: 103–7
7.
NatteroG, AllaisG, De LorenzoC, BenedettoC, ZoncaM, MelziE, MassobrioM.Relevance of prostaglandins in true menstrual migraine. Headache1989; 29: 233–8
8.
BornGVR. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature1962; 194: 927–9
9.
CouchJR, HassaneinRS.Platelet aggregability in migraine. Neurology1977; 27: 843–8
10.
DeshmukhSV, MeyerJS.Cyclic changes in platelet dynamics and the pathogenesis and prophylaxis of migraine. Headache1977; 17: 101–8
11.
FioroniL, MartignoniE, FacchinettiF.Changes in neuroendocrine axes in patients with menstrual migraine. Cephalalgia1995; 15: 297–300
