Causes of weakness are considered and attention is drawn to those that may be capable of amelioration. The mechanisms of cancer cachexia are reviewed. The role of reduced food intake, negative energy balance and metabolic changes occurring in cancer patients is examined.
Bruera E., MacDonald RN. Nutrition in cancer patients: an update and review of our experience . Journal of Pain and Symptom Management1988 ; 3: 133-40.
4.
Norton JA, Moley JF, Green MV, Carson RE, Morrison SDParabiotic transfer of cancer anorexia/cachexia in male rats. Cancer Res1985; 45: 5547-52.
5.
Balkwill F., Burke F., Talbot D. et al. Evidence for tumour necrosis factor/cachectin production in cancer. Lancet1987; 1229-32.
6.
Peutler B., Greenwald D., Hulmes JD et al. Identity of tumour necrosis factor and the macrophage-secreted factor cachectin. Nature1985; 316: 552-54.
Burt ME, Lowry SF, Gorschboth C., Brennan MFMetabolic alterations in a noncachectic animal tumour system. Cancer1981; 47: 2138-46.
14.
Holroyde CP , Reichard GACarbohydrate metabolism in cancer cachexia . Cancer Treat Rep1981; 65: 55-59.
15.
Norton JA, Maher M., Wesley R., White D., Brennan MFGlucose intolerance in sarcoma patients. Cancer1984; 54: 3022-27.
16.
Heber D., Byerly LO, Chlebowski RTMetabolic abnormalities in the cancer patient. Cancer1985; 55: 225-29.
17.
Heber D., Chlebowski RT, Ishibashi DE, Herrold JNBlock JBAbnormalities in glucose and protein metabolism in noncachectic lung cancer patients. Cancer Res1982; 42: 4815-1819.
18.
Holroyde CP , Gabuzdas TG, Putnam RC, Paul P., Reichard GAAltered glucose metabolism in metastatic carcinoma . Cancer Res1975; 35: 3710-14.
19.
Brennan MF, Burt MENitrogen metabolism in cancer patients. Cancer Treat Rep1981; 65: 67-78.
20.
Blackburn GL , Maini BS, Bistrian BR, McDermoot WVThe effect of cancer on nitrogen, electrolyte and mineral metabolism. Cancer Res1977; 37: 2348-53.
21.
Emery PW, Edwards Rht, Rennie MJ, Souhami RL, Halliday D.Protein synthesis in muscle measured in vivo in cachetic patients with cancer . Br Med J1984; 289: 584-86.
22.
Norton JA, Burt ME, Brennan MFIn vivo utilization of substrate by human sarcoma-bearing limbs. Cancer1980; 45: 2934-39.
23.
Waterhouse C., Jeanpretre N., Keilson J.Gluconeogensis from alanine in patients with progressive malignant disease. Cancer Res1979; 39: 1968-72.
24.
Garattini S. , Bizzi A., Donelli MG, Guaitani A., Samanin R., Spreafico F.Anorexia and cancer in animals and man. Cancer Treat Rev1980; 7: 115-40.
25.
Cohn SH, Gartenhaus W., Sawitsky A. et al. Compartmental body composition of cancer patients by measurement of total body nitrogen, potassium and water. Metabolism1981; 30: 222-29.
26.
Begg RWTumour-host relations. Adv Cancer Res1958 ; 5: 1-54.
27.
Brennan MFTotal parenteral nutrition in the cancer patient. N Engl J Med1981; 305: 375-82.
28.
Koretz RLParenteral nutrition: is it oncologically logical?J Clin Oncol1984; 2: 534-38.
29.
Evans WK, Nixon DW, Daly JM et al. A randomized study of oral nutritional support versus ad lib nutritional intake during chemotherapy for advanced colorectal and non-small-cell lung cancer. J Clin Oncol1987; 5: 113-24.
30.
Popp MB, Fisher RI, Wesley R., Aamodt R., Brennan MFA prospective randomized study of adjuvant parenteral nutrition in the treatment of advanced diffuse lymphoma: influence on survival. Surgery1981; 90: 195-202.
31.
Nixon DW, Moffitt S., Lawson DH et al. Total parenteral nutrition as an adjunct to chemotherapy of metastatic colorectal cancer. Cancer Treat Rep1981; 65: 121-28.
32.
Heber D., Byerley LO, Chi J. et al. Pathophysiology of malnutrition in the adult cancer patient. Cancer1986; 58: 1867-73.
33.
Chlebowski RT, Heber D., Richardson B., Block JBInfluence of hydrazine sulfate on abnormal carbohydrate metabolism in cancer patients with weight loss. Cancer Res1984; 44: 857-61.
34.
Chlebowski RT, Bulcavage L., Grosvenor M. et al. Hydrazine sulfate in cancer patients with weight loss. Cancer1987; 59: 406-10.
